Robinson, N. E. and Robinson, A. B. (2001) Deamidation of human proteins. Proceedings of the National Academy of Sciences of the United States of America, 98 (22). pp. 12409-12413. ISSN 0027-8424. PMCID PMC60067. doi:10.1073/pnas.221463198. https://resolver.caltech.edu/CaltechAUTHORS:20141119-132604985
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Abstract
Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2001 National Academy of Sciences. Communicated by Frederick Seitz, The Rockefeller University, New York, NY, August 31, 2001 (received for review May 8, 2001). Published ahead of print October 16, 2001. We thank Professor and Mrs. R. B. Merrifield for advice and encouragement, and the Kinsman foundation and other donors to the Oregon Institute of Science and Medicine for financial support. Additional information is available at www.deamidation.org. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. §1734 solely to indicate this fact. | |||||||||
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| Subject Keywords: | in vivo deamidation; asparaginyl residues | |||||||||
| Issue or Number: | 22 | |||||||||
| PubMed Central ID: | PMC60067 | |||||||||
| DOI: | 10.1073/pnas.221463198 | |||||||||
| Record Number: | CaltechAUTHORS:20141119-132604985 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141119-132604985 | |||||||||
| Official Citation: | Robinson, N. E., & Robinson, A. B. (2001). Deamidation of human proteins. Proceedings of the National Academy of Sciences, 98(22), 12409-12413. doi: 10.1073/pnas.221463198 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 51973 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Jason Perez | |||||||||
| Deposited On: | 19 Nov 2014 22:19 | |||||||||
| Last Modified: | 10 Nov 2021 19:18 |
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