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Genome-Wide Prediction of C. elegans Genetic Interactions

Zhong, Weiwei and Sternberg, Paul W. (2006) Genome-Wide Prediction of C. elegans Genetic Interactions. Science, 311 (5766). pp. 1481-1484. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141119-151713868

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Abstract

To obtain a global view of functional interactions among genes in a metazoan genome, we computationally integrated interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms—Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster—and predicted genome-wide genetic interactions in C. elegans. The resulting genetic interaction network (consisting of 18,183 interactions) provides a framework for system-level understanding of gene functions. We experimentally tested the predicted interactions for two human disease-related genes and identified 14 new modifiers.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1123287 DOIArticle
http://www.sciencemag.org/content/311/5766/1481PublisherArticle
http://www.sciencemag.org/content/311/5766/1481/suppl/DC1PublisherSupporting Information
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2006 American Association for the Advancement of Science. 1 December 2005; Accepted 26 January 2006. We thank the Caenorhabditis Genetics Center for strains; WormBase staff for discussions; L. Chen for advice on statistical analysis; B. Perry for maintaining reagents; and C. Van Buskirk, E. Hallem, B. Hwang, M. Kato, E. Kipreos, R. Kishore, A. Petcherski, and E. Schwarz for critical reading of the manuscript. P.W.S. is an investigator and W.Z. is an associate of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5766
Record Number:CaltechAUTHORS:20141119-151713868
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141119-151713868
Official Citation:Zhong, W., & Sternberg, P. W. (2006). Genome-Wide Prediction of C. elegans Genetic Interactions. Science, 311(5766), 1481-1484. doi: 10.1126/science.1123287
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51980
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:20 Nov 2014 00:46
Last Modified:03 Mar 2020 13:01

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