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Brief Notes on the Meaning of a Genomic Control System for Animal Embryogenesis

Davidson, Eric (2014) Brief Notes on the Meaning of a Genomic Control System for Animal Embryogenesis. Perspectives in Biology and Medicine, 57 (1). pp. 78-86. ISSN 0031-5982. http://resolver.caltech.edu/CaltechAUTHORS:20141120-083722985

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Abstract

This article presents some reflections on how the recently published Boolean gene regulatory network (GRN) model for sea urchin endomesoderm development affects the problem of what we can expect to know about a developmental process. The Boolean computation demonstrated that, on a system-wide level, a topological GRN model can contain sufficient regulatory information to predict in silico all the spatial and almost all the temporal processes of regulatory gene expression observed in this phase of embryonic development. Conclusions that can be drawn illuminate the general and fundamental characteristics of developmental regulatory systems, such as their innate hierarchy and their reliance on logic-processing functions. The automaton-like performance which the Boolean model displayed reflects the basic quality of genomically controlled developmental process. This quality is of course the underlying requirement for a genetically encoded developmental mechanism. The accessibility of system-wide mechanistic explanation is something new in developmental biology, and turns on their head old truisms that for a century have been implicit in science aimed at small parts of systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1353/pbm.2014.0009DOIArticle
http://muse.jhu.edu/journals/perspectives_in_biology_and_medicine/v057/57.1.davidson.htmlPublisherArticle
Additional Information:© 2014 by Johns Hopkins University Press. This work was supported by a grant from the National Institute for Child Health and Development. The ideas discussed were all developed with my colleague Isabelle S. Peter, coauthor of the automaton computation that is the subject of this commentary.
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Funding AgencyGrant Number
National Institute for Child Health and DevelopmentUNSPECIFIED
Record Number:CaltechAUTHORS:20141120-083722985
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141120-083722985
Official Citation:Eric Davidson. "Brief Notes on the Meaning of a Genomic Control System for Animal Embryogenesis." Perspectives in Biology and Medicine 57.1 (2014): 78-86. Project MUSE. Web. 20 Nov. 2014. <http://muse.jhu.edu/>
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:51989
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Nov 2014 16:51
Last Modified:20 Nov 2014 16:51

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