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Atypical expansion in mice of the sensory neuronspecific Mrg G protein-coupled receptor family

Zylka, Mark J. and Dong, Xinzhong and Southwell, Amber L. and Anderson, David J. (2003) Atypical expansion in mice of the sensory neuronspecific Mrg G protein-coupled receptor family. Proceedings of the National Academy of Sciences of the United States of America, 100 (17). pp. 10043-10048. ISSN 0027-8424. PMCID PMC187757. https://resolver.caltech.edu/CaltechAUTHORS:20141120-150144380

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Abstract

The Mas-related genes (Mrgs) comprise a family of >50 G protein-coupled receptors (GPCRs), many of which are expressed in specific subsets of nociceptive sensory neurons in mice. In contrast, humans contain a related but nonorthologous family of genes, called MrgXs or sensory neuron-specific receptors, of which many fewer appear to be expressed in sensory neurons. To determine whether the diversity of murine Mrgs is generic to rodents or is an atypical feature of mice, we characterized MrgA, MrgB, MrgC, and MrgD subfamilies in rat and gerbil. Surprisingly, although mice have ≈22 MrgA and ≈14 MrgC genes, rats and gerbils have just a single MrgA and MrgC gene. This murine-specific expansion likely reflects recent retrotransposon-mediated unequal crossover events. The expression of Mrgs in rat sensory ganglia suggests that the extensive cellular diversity in mice can be simplified to a core subset of approximately four different genes (MrgA, MrgB, MrgC, and MrgD), defining a similar number of neuronal subpopulations. Our results suggest more generally that mouse–human genomic comparisons may sometimes reveal differences atypical of rodents.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1732949100DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc187757/PubMed CentralArticle
ORCID:
AuthorORCID
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2003 The National Academy of Sciences. Received May 15, 2003. We thank Gaby Mosconi for laboratory management; Jung-Sook Chang for technical assistance; Mel Simon, Sang-Kyou Han, and Jong-Ik Hwang for helpful discussions throughout the course of this work; and Mel Simon and Cori Bargmann for comments on the manuscript. M.J.Z. was supported by the Cancer Research Fund of the Damon Runyon–Walter Winchell Foundation Fellowship (DRG-1581). X.D. is a postdoctoral fellow of the American Cancer Society, and D.J.A. is an Investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Damon Runyon–Walter Winchell FoundationDRG-1581
American Cancer SocietyUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:17
PubMed Central ID:PMC187757
Record Number:CaltechAUTHORS:20141120-150144380
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141120-150144380
Official Citation:Zylka, M. J., Dong, X., Southwell, A. L., & Anderson, D. J. (2003). Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Proceedings of the National Academy of Sciences, 100(17), 10043-10048. doi: 10.1073/pnas.1732949100
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52017
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:21 Nov 2014 17:37
Last Modified:03 Jun 2020 23:35

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