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Cognitive Control Signals for Neural Prosthetics

Musallam, S. and Corneil, B. D. and Greger, B. and Scherberger, H. and Andersen, R. A. (2004) Cognitive Control Signals for Neural Prosthetics. Science, 305 (5681). pp. 258-262. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141121-110153014

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Abstract

Recent development of neural prosthetics for assisting paralyzed patients has focused on decoding intended hand trajectories from motor cortical neurons and using this signal to control external devices. In this study, higher level signals related to the goals of movements were decoded from three monkeys and used to position cursors on a computer screen without the animals emitting any behavior. Their performance in this task improved over a period of weeks. Expected value signals related to fluid preference, the expected magnitude, or probability of reward were decoded simultaneously with the intended goal. For neural prosthetic applications, the goal signals can be used to operate computers, robots, and vehicles, whereas the expected value signals can be used to continuously monitor a paralyzed patient's preferences and motivation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1097938DOIArticle
http://www.sciencemag.org/content/305/5681/258PublisherArticle
http://www.sciencemag.org/content/305/5681/258/suppl/DC1PublisherSupporting Online Material
Additional Information:© 2004 American Association for the Advancement of Science. Received 16 March 2004; accepted 7 June 2004. We thank J. Burdick, D. Meeker, B. Pesaran, D. Rizzuto, and S. Cao for helpful discussion during the course of this study; G. Mulliken and R. Battacharyya for help with data collection; B. Grieve, K. Pejsa, and L. Martel for help with animal handling and training; K. Bernheim for help with the magnetic resonance imaging; J. Baer and C. Lindsell for veterinary assistance; I. Fineman for surgical help; V. Shcherbatyuk for computer support; and T. Yao for administrative support. We thank the Defense Advanced Research Projects Agency (DARPA), the National Eye Institute (NEI), the Office of Naval Research (ONR), the James G. Boswell Foundation NSF, the Sloan-Swartz Center for Theoretical Neurobiology at the California Institute of Technology, and the Christopher Reeve Paralysis Foundation for supporting this research. B.D.C. was supported by a long-term fellowship from the Human Frontier Science Program.
Funders:
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
National Eye Institute (NEI)UNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
NSFUNSPECIFIED
Caltech Sloan-Swartz Center for Theoretical NeurobiologyUNSPECIFIED
Christopher Reeve Paralysis FoundationUNSPECIFIED
Human Frontier Science Program (HFSP)UNSPECIFIED
Issue or Number:5681
Record Number:CaltechAUTHORS:20141121-110153014
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141121-110153014
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52044
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Nov 2014 20:44
Last Modified:03 Oct 2019 07:38

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