A Caltech Library Service

A model for MRI contrast enhancement using T_1 agents

Ahrens, E. T. and Rothbächer, U. and Jacobs, R. E. and Fraser, S. E. (1998) A model for MRI contrast enhancement using T_1 agents. Proceedings of the National Academy of Sciences of the United States of America, 95 (15). pp. 8443-8448. ISSN 0027-8424. PMCID PMC21095.

PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Contrast in MRI relies on differences in the local environment of water and is often enhanced by using contrast agents. We present a simple model for evaluating the minimal contrast agent concentration required to produce “satisfactory” contrast enhancement in magnetic resonance images. Previous strategies have been based largely on empirical results for specific systems. The present tissue contrast model (TCM) can be applied to “conventional,” targeted, or biochemically responsive agents. The model results are formulated so that only a small number of parameters are required to analyze a given scenario. The TCM is a particularly useful tool in the development of new classes of magnetic resonance contrast media. These agents will have the ability to target specific cells or tissue, and perhaps be able to report on their physiological status. As an example of the applicability of the TCM, we test it against in vivo magnetic resonance microscopy results in frog embryos that have focal cell populations labeled with contrast agent by using calibrated single-cell microinjection techniques.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Jacobs, R. E.0000-0002-1382-8486
Fraser, S. E.0000-0002-5377-0223
Alternate Title:A model for MRI contrast enhancement using T1 agents
Additional Information:© 1998 National Academy of Sciences. Communicated by Marcus E. Raichle, Washington University School of Medicine, St. Louis, MO (received for review August 1, 1997) Accepted May 6, 1998. We thank P. T. Narasimhan, David Laidlaw, Rex Moats, and Thomas Meade for helpful discussions. E.T.A. acknowledges support from the National Institute of Neurological Disorders and Stroke Grant F32 NS10384. This work was supported in part by the Human Brain Project funded jointly by the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Science Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked ‘‘advertisement’’ in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)F32 NS10384
Human Brain ProjectUNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Issue or Number:15
PubMed Central ID:PMC21095
Record Number:CaltechAUTHORS:20141121-152538924
Persistent URL:
Official Citation:E. T. Ahrens, U. Rothbächer, R. E. Jacobs, and S. E. Fraser A model for MRI contrast enhancement using T1 agents PNAS 1998 95 (15) 8443-8448
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52064
Deposited By: George Porter
Deposited On:21 Nov 2014 23:42
Last Modified:03 Oct 2019 07:38

Repository Staff Only: item control page