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Stem-Cell Homeostasis and Growth Dynamics Can Be Uncoupled in the Arabidopsis Shoot Apex

Reddy, G. Venugopala and Meyerowitz, Elliot M. (2005) Stem-Cell Homeostasis and Growth Dynamics Can Be Uncoupled in the Arabidopsis Shoot Apex. Science, 310 (5748). pp. 663-667. ISSN 0036-8075. doi:10.1126/science.1116261. https://resolver.caltech.edu/CaltechAUTHORS:20141121-153340056

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Abstract

The shoot apical meristem (SAM) is a collection of stem cells that resides at the tip of each shoot and provides the cells of the shoot. It is divided into functional regions. The central zone (CZ) at the tip of the meristem is the domain of expression of the CLAVATA3 (CLV3) gene, encoding a putative ligand for a transmembrane receptor kinase, CLAVATA1, active in cells of the rib meristem (RM), located just below the CZ. We show here that CLV3 restricts its own domain of expression (the CZ) by preventing differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ cells and restricts overall SAM size by a separate, long-range effect on cell division rate.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1116261DOIArticle
http://www.sciencemag.org/content/310/5748/663PublisherArticle
http://www.sciencemag.org/content/310/5748/663/suppl/DC1PublisherSupporting Information
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 2005 American Association for the Advancement of Science. 17 June 2005; Accepted 26 September 2005; Published online 6 October 2005. We thank C.-F. Chuang, I. Moore, R. Simon, and D. Ehrhardt for DNA constructs and members of the Meyerowitz laboratory for comments on the manuscript. G.V.R. was a fellow of the Jane Coffin Childs memorial fund for medical research, and this work was supported by U.S. National Science Foundation grant IOB-0211670.
Funders:
Funding AgencyGrant Number
Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
NSFIOB-0211670
Issue or Number:5748
DOI:10.1126/science.1116261
Record Number:CaltechAUTHORS:20141121-153340056
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141121-153340056
Official Citation:Reddy, G. V., & Meyerowitz, E. M. (2005). Stem-Cell Homeostasis and Growth Dynamics Can Be Uncoupled in the Arabidopsis Shoot Apex. Science 28 Oct 2005: Vol. 310, Issue 5748, pp. 663-667 DOI: 10.1126/science.1116261
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52065
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:22 Nov 2014 00:09
Last Modified:10 Nov 2021 19:20

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