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Electron Transfer Between Bases in Double Helical DNA

Kelley, Shana O. and Barton, Jacqueline K. (1999) Electron Transfer Between Bases in Double Helical DNA. Science, 283 (5400). pp. 375-381. ISSN 0036-8075. doi:10.1126/science.283.5400.375. https://resolver.caltech.edu/CaltechAUTHORS:20141124-090349421

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Abstract

Fluorescent analogs of adenine that selectively oxidize guanine were used to investigate photoinduced electron transfer through the DNA π-stack as a function of reactant stacking and energetics. Small variations in these factors led to profound changes in the kinetics and distance dependences of DNA-mediated electron-transfer reactions. Values of β, a parameter reflecting the dependence of electron transfer on distance, ranged from 0.1 to 1.0 per angstrom. Strong stacking interactions result in the fastest electron-transfer kinetics. Electrons are thus transported preferentially through an intrastrand rather than interstrand pathway. Reactant energetics also modulate the distance dependence of DNA-mediated charge transport. These studies may resolve the range of disparate results previously reported, and paradigms must now be developed to describe these properties of the DNA π-stack, which can range from insulator- to “wire”-like.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.283.5400.375DOIArticle
http://www.sciencemag.org/content/283/5400/375PublisherArticle
ORCID:
AuthorORCID
Kelley, Shana O.0000-0003-3360-5359
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1999 American Association for the Advancement of Science. Received 30 September 1998; accepted 9 December 1998. This research was supported by the Office of Naval Research and in part by NSF (grants CTS-9311741 and CHE-9120001) and an Elon Huntington Hooker Fellowship to X.L.C.
Funders:
Funding AgencyGrant Number
Office of Naval Research (ONR)UNSPECIFIED
NSFCTS-9311741
NSFCHE-9120001
Elon Huntington Hooker FellowshipUNSPECIFIED
Issue or Number:5400
DOI:10.1126/science.283.5400.375
Record Number:CaltechAUTHORS:20141124-090349421
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141124-090349421
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52085
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Nov 2014 21:32
Last Modified:10 Nov 2021 19:20

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