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Preventing Neurodegeneration in the Drosophila Mutant bubblegum

Min, Kyung-Tai and Benzer, Seymour (1999) Preventing Neurodegeneration in the Drosophila Mutant bubblegum. Science, 284 (5422). pp. 1985-1988. ISSN 0036-8075. doi:10.1126/science.284.5422.1985.

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The Drosophila melanogaster recessive mutantbubblegum (bgm) exhibits adult neurodegeneration, with marked dilation of photoreceptor axons. The bubblegummutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the human disease adrenoleukodystrophy (ALD). In ALD, the excess can be lowered by dietary treatment with “Lorenzo's oil,” a mixture of unsaturated fatty acids. Feeding the fly mutant one of the components, glyceryl trioleate oil, blocked the accumulation of excess VLCFAs as well as development of the pathology. Mutant flies thus provide a potential model system for studying mechanisms of neurodegenerative disease and screening drugs for treatment.

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Additional Information:© 1999 American Association for the Advancement of Science. Received 25 January 1999; accepted 29 April 1999. We thank R. Young, C. Kang, and A. Gomez for expert technical support and members of our research group for helpful discussions. Supported by a postdoctoral fellowship from the Dell Webb Foundation (K.-T.M.) and by grants (S.B.) from NSF, NIH, and the James G. Boswell Foundation.
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Dell Webb FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Issue or Number:5422
Record Number:CaltechAUTHORS:20141124-093010451
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52088
Deposited By: Tony Diaz
Deposited On:24 Nov 2014 21:30
Last Modified:10 Nov 2021 19:20

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