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Neural Crest Specification Regulated by the Helix-Loop-Helix Repressor Id2

Martinsen, Brad J. and Bronner-Fraser, Marianne (1998) Neural Crest Specification Regulated by the Helix-Loop-Helix Repressor Id2. Science, 281 (5379). pp. 988-991. ISSN 0036-8075. doi:10.1126/science.281.5379.988.

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Vertebrate neural crest cells, derived from the neural folds, generate a variety of tissues, such as cartilage, ganglia, and cranial (intramembranous) bone. The chick homolog of the helix-loop-helix transcriptional regulator Id2 is expressed in cranial but not trunk neural folds and subsequently in some migrating cranial neural crest cells. Ectopic expression of Id2 with recombinant retroviruses converted ectodermal cells to a neural crest fate, demonstrating that proper regulation of Id2 is important for sustaining epidermal traits. In addition, overexpression of Id2 resulted in overgrowth and premature neurogenesis of the dorsal neural tube. These results suggest that Id2 may allocate ectodermal precursors into neural rather than epidermal lineages.

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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1998 American Association for the Advancement of Science. Received 16 March 1998; accepted 1 July 1998. We thank S. Fraser, C. Baker, and M. Dickinson for critical reading of the manuscript; J. Sechrist for critical analysis of ectoderm conversion data; C. Marcelle, T. Moreno, M. Barembaum, and C. LaBonne for advice on molecular biology protocols; and K. Min and J. Neri for cryostat sectioning. We are grateful to S. Bryant and D. Gardiner for the stage 13 to 24 chick embryo library. Supported by U.S. Public Health Service grants NS34671 and NS36585.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)NS34671
U.S. Public Health Service (USPHS)NS36585
Issue or Number:5379
Record Number:CaltechAUTHORS:20141124-104739069
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52095
Deposited By: Tony Diaz
Deposited On:24 Nov 2014 21:20
Last Modified:10 Nov 2021 19:20

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