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Genomic Cis-Regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene

Yuh, Chiou-Hwa and Bolouri, Hamid and Davidson, Eric H. (1998) Genomic Cis-Regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene. Science, 279 (5358). pp. 1896-1902. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20141124-122830535

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Abstract

The genomic regulatory network that controls gene expression ultimately determines form and function in each species. The operational nature of the regulatory programming specified in cis-regulatory DNA sequence was determined from a detailed functional analysis of a sea urchin control element that directs the expression of a gene in the endoderm during development. Spatial expression and repression, and the changing rate of transcription of this gene, are mediated by a complex and extended cis-regulatory system. The system may be typical of developmental cis-regulatory apparatus. All of its activities are integrated in the proximal element, which contains seven target sites for DNA binding proteins. A quantitative computational model of this regulatory element was constructed that explicitly reveals the logical interrelations hard-wired into the DNA.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.279.5358.1896DOIArticle
http://www.sciencemag.org/content/279/5358/1896PublisherArticle
Additional Information:© 1998 American Association for the Advancement of Science. Received 15 October 1997; accepted 26 January 1998. We thank R. J. Britten and J. A. Coffman for perspicacious and critical reviews of this manuscript. We also thank many other colleagues who have discussed this work with us. Supported by a grant from the National Institute of Child Health and Human Development and by the Stowers Institute for Medical Research.
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Funding AgencyGrant Number
National Institute of Child Health and Human Development (NICHD)UNSPECIFIED
Stowers Institute for Medical ResearchUNSPECIFIED
Record Number:CaltechAUTHORS:20141124-122830535
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141124-122830535
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52104
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Nov 2014 20:59
Last Modified:23 Dec 2015 22:41

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