A Caltech Library Service

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Lin, Yi-Jyun and Seroude, Laurent and Benzer, Seymour (1998) Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah. Science, 282 (5390). pp. 943-946. ISSN 0036-8075. doi:10.1126/science.282.5390.943.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah(mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.

Item Type:Article
Related URLs:
URLURL TypeDescription
Additional Information:© 1998 American Association for the Advancement of Science. Received 14 July 1998; accepted 25 September 1998. Supported by a Postdoctoral Research Fellowship from the John Douglas French Alzheimer Foundation ( Y.-J.L.) and grants from the National Science Foundation (MCB9408718), the National Institutes of Health (EY09278 and AG12289), and the James G. Boswell Foundation (S.B.).
Funding AgencyGrant Number
John Douglas French Alzheimer FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Issue or Number:5390
Record Number:CaltechAUTHORS:20141124-124442950
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52106
Deposited By: Tony Diaz
Deposited On:24 Nov 2014 20:57
Last Modified:10 Nov 2021 19:20

Repository Staff Only: item control page