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Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

Lin, Yi-Jyun and Seroude, Laurent and Benzer, Seymour (1998) Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah. Science, 282 (5390). pp. 943-946. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141124-124442950

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Abstract

Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah(mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.282.5390.943DOIArticle
http://www.sciencemag.org/content/282/5390/943PublisherArticle
Additional Information:© 1998 American Association for the Advancement of Science. Received 14 July 1998; accepted 25 September 1998. Supported by a Postdoctoral Research Fellowship from the John Douglas French Alzheimer Foundation ( Y.-J.L.) and grants from the National Science Foundation (MCB9408718), the National Institutes of Health (EY09278 and AG12289), and the James G. Boswell Foundation (S.B.).
Funders:
Funding AgencyGrant Number
John Douglas French Alzheimer FoundationUNSPECIFIED
NSFMCB9408718
NIHEY09278
NIHAG12289
James G. Boswell FoundationUNSPECIFIED
Issue or Number:5390
Record Number:CaltechAUTHORS:20141124-124442950
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141124-124442950
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52106
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Nov 2014 20:57
Last Modified:03 Oct 2019 07:39

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