Lin, Yi-Jyun and Seroude, Laurent and Benzer, Seymour (1998) Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah. Science, 282 (5390). pp. 943-946. ISSN 0036-8075. doi:10.1126/science.282.5390.943. https://resolver.caltech.edu/CaltechAUTHORS:20141124-124442950
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Abstract
Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah(mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate–binding protein–coupled seven–transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
Item Type: | Article | ||||||||||||
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Additional Information: | © 1998 American Association for the Advancement of Science. Received 14 July 1998; accepted 25 September 1998. Supported by a Postdoctoral Research Fellowship from the John Douglas French Alzheimer Foundation ( Y.-J.L.) and grants from the National Science Foundation (MCB9408718), the National Institutes of Health (EY09278 and AG12289), and the James G. Boswell Foundation (S.B.). | ||||||||||||
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Issue or Number: | 5390 | ||||||||||||
DOI: | 10.1126/science.282.5390.943 | ||||||||||||
Record Number: | CaltechAUTHORS:20141124-124442950 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141124-124442950 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 52106 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 24 Nov 2014 20:57 | ||||||||||||
Last Modified: | 10 Nov 2021 19:20 |
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