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Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis

Jacobsen, Steven E. and Meyerowitz, Elliot M. (1997) Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis. Science, 277 (5329). pp. 1100-1103. ISSN 0036-8075. doi:10.1126/science.277.5329.1100.

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Mutations in the SUPERMAN gene affect flower development in Arabidopsis. Seven heritable but unstable supepi-alleles (the clark kent alleles) are associated with nearly identical patterns of excess cytosine methylation within theSUP gene and a decreased level of SUP RNA. Revertants of these alleles are largely demethylated at theSUP locus and have restored levels of SUP RNA. A transgenic Arabidopsis line carrying an antisense methyltransferase gene, which shows an overall decrease in genomic cytosine methylation, also contains a hypermethylated supallele. Thus, disruption of methylation systems may yield more complex outcomes than expected and can result in methylation defects at known genes. The clark kent alleles differ from the antisense line because they do not show a general decrease in genomic methylation.

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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1997 American Association for the Advancement of Science. 10 April 1997; accepted 11 July 1997. We thank G. Serraiocco for technical assistance, H. Sakai for SUP genomic sequences and cosmid clones, E. Finnegan and E. Dennis for the AMT line, D. Weigel for clk-5, J. Viret and E. Signer for clk-6, and X. Chen, J. Fletcher, M. Frohlich, J. Hua, C. Ohno, J. L. Riechmann, R. Sablowski, H. Sakai, D. Wagner, and E. Ziegelhoffer for review of the manuscript. S.E.J. was supported by an NIH postdoctoral fellowship. This work was supported by NSF grant MCB-9204839 to E.M.M.
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NIH Postdoctoral FellowshipUNSPECIFIED
Issue or Number:5329
Record Number:CaltechAUTHORS:20141124-133530779
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Official Citation:Jacobsen, S. E., & Meyerowitz, E. M. (1997). Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis. Science, 277(5329), 1100-1103. doi: 10.1126/science.277.5329.1100
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ID Code:52114
Deposited On:25 Nov 2014 00:27
Last Modified:10 Nov 2021 19:21

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