CaltechAUTHORS
  A Caltech Library Service

Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis

Jacobsen, Steven E. and Meyerowitz, Elliot M. (1997) Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis. Science, 277 (5329). pp. 1100-1103. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141124-133530779

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20141124-133530779

Abstract

Mutations in the SUPERMAN gene affect flower development in Arabidopsis. Seven heritable but unstable supepi-alleles (the clark kent alleles) are associated with nearly identical patterns of excess cytosine methylation within theSUP gene and a decreased level of SUP RNA. Revertants of these alleles are largely demethylated at theSUP locus and have restored levels of SUP RNA. A transgenic Arabidopsis line carrying an antisense methyltransferase gene, which shows an overall decrease in genomic cytosine methylation, also contains a hypermethylated supallele. Thus, disruption of methylation systems may yield more complex outcomes than expected and can result in methylation defects at known genes. The clark kent alleles differ from the antisense line because they do not show a general decrease in genomic methylation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.277.5329.1100 DOIArticle
http://www.sciencemag.org/content/277/5329/1100PublisherArticle
ORCID:
AuthorORCID
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1997 American Association for the Advancement of Science. 10 April 1997; accepted 11 July 1997. We thank G. Serraiocco for technical assistance, H. Sakai for SUP genomic sequences and cosmid clones, E. Finnegan and E. Dennis for the AMT line, D. Weigel for clk-5, J. Viret and E. Signer for clk-6, and X. Chen, J. Fletcher, M. Frohlich, J. Hua, C. Ohno, J. L. Riechmann, R. Sablowski, H. Sakai, D. Wagner, and E. Ziegelhoffer for review of the manuscript. S.E.J. was supported by an NIH postdoctoral fellowship. This work was supported by NSF grant MCB-9204839 to E.M.M.
Funders:
Funding AgencyGrant Number
NIH Postdoctoral FellowshipUNSPECIFIED
NSFMCB-9204839
Issue or Number:5329
Record Number:CaltechAUTHORS:20141124-133530779
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141124-133530779
Official Citation:Jacobsen, S. E., & Meyerowitz, E. M. (1997). Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis. Science, 277(5329), 1100-1103. doi: 10.1126/science.277.5329.1100
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52114
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:25 Nov 2014 00:27
Last Modified:03 Oct 2019 07:39

Repository Staff Only: item control page