Fletcher, Jennifer C. and Brand, Ulrike and Running, Mark P. and Rüdiger, Simon and Meyerowitz, Elliot M. (1999) Signaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems. Science, 283 (5409). pp. 1911-1914. ISSN 0036-8075. doi:10.1126/science.283.5409.1911. https://resolver.caltech.edu/CaltechAUTHORS:20141125-090158403
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Abstract
In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1,2, and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1, which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation.CLV3 encodes a small, predicted extracellular protein.CLV3 acts nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.
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| Additional Information: | © 1999 American Association for the Advancement of Science. Received 15 December 1998; accepted 24 February 1999. We thank E. Wisman, B. Williams, and S. Jacobsen for clv3 alleles, the Arabidopsis Biological Resource Center at Ohio State University for seeds, J. Wong and N. Beinert for technical assistance, B. Williams for sharing unpublished data, and members of the Meyerowitz Lab for discussion. This work was supported by the U.S. National Institutes of Health ( J.C.F.), the Howard Hughes Medical Institute (M.P.R.), the Deutsche Forschungsgemeinschaft (SFB 243, R.S. and U.B.), the National Science Foundation (E.M.M.), and Zeneca Seeds (E.M.M.). | ||||||||||||
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| Issue or Number: | 5409 | ||||||||||||
| DOI: | 10.1126/science.283.5409.1911 | ||||||||||||
| Record Number: | CaltechAUTHORS:20141125-090158403 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141125-090158403 | ||||||||||||
| Official Citation: | Signaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems BY JENNIFER C. FLETCHER, ULRIKE BRAND, MARK P. RUNNING, RÜDIGER SIMON, ELLIOT M. MEYEROWITZ Science 19 Mar 1999: Vol. 283, Issue 5409, pp. 1911-1914 DOI: 10.1126/science.283.5409.1911 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 52127 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||
| Deposited On: | 25 Nov 2014 20:35 | ||||||||||||
| Last Modified: | 10 Nov 2021 19:21 |
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