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Organization of an echinoderm Hox gene cluster

Martinez, Pedro and Rast, Jonathan P. and Arenas-Mena, César and Davidson, Eric H. (1999) Organization of an echinoderm Hox gene cluster. Proceedings of the National Academy of Sciences of the United States of America, 96 (4). pp. 1469-1474. ISSN 0027-8424. PMCID PMC15486. doi:10.1073/pnas.96.4.1469. https://resolver.caltech.edu/CaltechAUTHORS:20141125-151903783

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Abstract

The Strongylocentrotus purpuratus genome contains a single ten-gene Hox complex >0.5 megabase in length. This complex was isolated on overlapping bacterial artificial chromosome and P1 artificial chromosome genomic recombinants by using probes for individual genes and by genomic walking. Echinoderm Hox genes of Paralog Groups (PG) 1 and 2 are reported. The cluster includes genes representing all paralog groups of vertebrate Hox clusters, except that there is a single gene of the PG4–5 types and only three genes of the PG9–12 types. The echinoderm Hox gene cluster is essentially similar to those of the bilaterally organized chordates, despite the radically altered pentameral body plans of these animals.


Item Type:Article
Related URLs:
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http://dx.doi.org/10.1073/pnas.96.4.1469DOIArticle
http://www.pnas.org/content/96/4/1469PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC15486/PubMed CentralArticle
Additional Information:© 1999 The National Academy of Sciences. Contributed by Eric H. Davidson, December 18, 1998. It is a pleasure to acknowledge the expert assistance of Dr. Kevin Peterson of this laboratory in the phylogenetic analyses of Hox gene sequences referred to throughout this work and also for helpful critical comments on the manuscript. We are extremely grateful to Drs. Ellen Popodi (Indiana University), Robert Maxson (University of Southern California), Michael Murtha (Yale University), and Giovanni Spinnelli (University of Palermo) for providing us with Hox probes from various sea urchin species. We thank Valeria Mancino for help with pulsed-field electrophoresis. Drs. Chris Amemiya and Pieter de Jong were extremely helpful in providing us with their PAC and BAC vectors, respectively. This work was supported by the Stowers Institute for Medical Research and by a grant from the National Institute of Child Health and Human Development. J.P.R. was supported by a National Institutes of Health Training Grant (HD-07257). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked ‘‘advertisement’’ in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Stowers Institute for Medical ResearchUNSPECIFIED
National Institute of Child Health and Human DevelopmentUNSPECIFIED
NIH Training GrantHD-07257
Issue or Number:4
PubMed Central ID:PMC15486
DOI:10.1073/pnas.96.4.1469
Record Number:CaltechAUTHORS:20141125-151903783
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141125-151903783
Official Citation:Martinez, P., Rast, J. P., Arenas-Mena, C., & Davidson, E. H. (1999). Organization of an echinoderm Hox gene cluster. Proceedings of the National Academy of Sciences, 96(4), 1469-1474. doi: 10.1073/pnas.96.4.1469
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52164
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:26 Nov 2014 15:46
Last Modified:10 Nov 2021 19:22

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