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Oxidative Thymine Dimer Repair in the DNA Helix

Dandliker, Peter J. and Holmlin, R. Erik and Barton, Jacqueline K. (1997) Oxidative Thymine Dimer Repair in the DNA Helix. Science, 275 (5305). pp. 1465-1468. ISSN 0036-8075. doi:10.1126/science.275.5305.1465.

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The metallointercalator Rh(phi)_2DMB^(3+) (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4′-dimethyl-2,2′-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening π-stack.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1997 American Association for the Advancement of Science. Received 24 July 1996; accepted 23 January 1997. Supported by NIH grant GM49216, a postdoctoral fellowship from the Cancer Research Fund of the Damon Runyon–Walter Winchell Foundation (P.J.D.), and an NSF predoctoral fellowship (R.E.H.). We thank N. J. Turro and E. D. A. Stemp for helpful discussions.
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Damon Runyon–Walter Winchell FoundationUNSPECIFIED
NSF predoctoral fellowshipUNSPECIFIED
Issue or Number:5305
Record Number:CaltechAUTHORS:20141126-103406641
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Official Citation:Oxidative Thymine Dimer Repair in the DNA Helix Peter J. Dandliker, R. Erik Holmlin, and Jacqueline K. Barton Science 7 March 1997: 275 (5305), 1465-1468. [DOI:10.1126/science.275.5305.1465]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52179
Deposited By: Tony Diaz
Deposited On:27 Nov 2014 15:06
Last Modified:10 Nov 2021 19:22

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