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Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events

Sutton, Michael A. and Wall, Nicholas R. and Aakalu, Girish N. and Schuman, Erin M. (2004) Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events. Science, 304 (5679). pp. 1979-1983. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141126-115242838

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Abstract

We examined dendritic protein synthesis after a prolonged blockade of action potentials alone and after a blockade of both action potentials and miniature excitatory synaptic events (minis). Relative to controls, dendrites exposed to a prolonged blockade of action potentials showed diminished protein synthesis. Dendrites in which both action potentials and minis were blocked showed enhanced protein synthesis, suggesting that minis inhibit dendritic translation. When minis were acutely blocked or stimulated, an immediate increase or decrease, respectively, in dendritic translation was observed. Taken together, these results reveal a role for miniature synaptic events in the acute regulation of dendritic protein synthesis in neurons.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1096202DOIArticle
http://www.sciencemag.org/content/304/5679/1979PublisherArticle
http://www.sciencemag.org/content/304/5679/1979/suppl/DC1PublisherSupporting Information
ORCID:
AuthorORCID
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 2004 American Association for the Advancement of Science. 29 January 2004; Accepted 12 May 2004. We thank G. Patrick, C. Jiang, and C.-Y. Tai for critically reading the manuscript, H. Weld for making beautiful cultured hippocampal neurons, and all members of the Schuman lab. Supported by the Damon Runyon Walter Winchell Fund (M.A.S.) and the NIH (E.M.S.). E.M.S. is an associate investigator of HHMI.
Funders:
Funding AgencyGrant Number
Damon Runyon Walter Winchell FundUNSPECIFIED
NIHUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5679
Record Number:CaltechAUTHORS:20141126-115242838
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141126-115242838
Official Citation:Sutton, M. A., Wall, N. R., Aakalu, G. N., & Schuman, E. M. (2004). Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events. Science, 304(5679), 1979-1983. doi: 10.1126/science.1096202
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52181
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:26 Nov 2014 20:24
Last Modified:09 Mar 2020 13:19

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