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Activity-Dependent Cortical Target Selection by Thalamic Axons

Catalano, Susan M. and Shatz, Carla J. (1998) Activity-Dependent Cortical Target Selection by Thalamic Axons. Science, 281 (5376). pp. 559-562. ISSN 0036-8075. doi:10.1126/science.281.5376.559.

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Connections in the developing nervous system are thought to be formed initially by an activity-independent process of axon pathfinding and target selection and subsequently refined by neural activity. Blockade of sodium action potentials by intracranial infusion of tetrodotoxin in cats during the early period when axons from the lateral geniculate nucleus (LGN) were in the process of selecting visual cortex as their target altered the pattern and precision of this thalamocortical projection. The majority of LGN neurons, rather than projecting to visual cortex, elaborated a significant projection within the subplate of cortical areas normally bypassed. Those axons that did project to their correct target were topographically disorganized. Thus, neural activity is required for initial targeting decisions made by thalamic axons as they traverse the subplate.

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Additional Information:© 1998 American Association for the Advancement of Science. Received 12 March 1998; accepted 10 June 1998. We thank A. Raymond and D. Escontrias for help with the fetal surgeries. Supported by NIH grant EY02838 (C.J.S.) and National Research Service Award EY06491 (S.M.C.). S.M.C. is an Associate and C.J.S. is an Investigator of the Howard Hughes Medical Institute.
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Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5376
Record Number:CaltechAUTHORS:20141202-123859457
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Official Citation:Activity-Dependent Cortical Target Selection by Thalamic Axons Susan M. Catalano and Carla J. Shatz Science 24 July 1998: 281 (5376), 559-562. [DOI:10.1126/science.281.5376.559]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52273
Deposited By: Tony Diaz
Deposited On:02 Dec 2014 21:11
Last Modified:10 Nov 2021 19:23

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