A Caltech Library Service

Specification of the Zebrafish Nervous System by Nonaxial Signals

Woo, Katherine and Fraser, Scott E. (1997) Specification of the Zebrafish Nervous System by Nonaxial Signals. Science, 277 (5323). pp. 254-257. ISSN 0036-8075. doi:10.1126/science.277.5323.254.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


The organizer of the amphibian gastrula provides the neurectoderm with both neuralizing and posteriorizing (transforming) signals. In zebrafish, transplantations show that a spatially distinct transformer signal emanates from tissues other than the organizer. Cells of the germring (nonaxial mesendoderm) posteriorized forebrain progenitors when grafted nearby, resulting in an ectopic hindbrain-like structure; in contrast, cells of the organizer (axial mesendoderm) caused no posterior transformation. Local application of basic fibroblast growth factor, a candidate transformer in Xenopus, caused malformation but not hindbrain transformation in the forebrain. Thus, the zebrafish gastrula may integrate spatially distinct signals from the organizer and the germring to pattern the neural axis.

Item Type:Article
Related URLs:
URLURL TypeDescription
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1997 American Association for the Advancement of Science. Received 8 October 1996; accepted 27 May 1997. We thank T. Jowett and E. Weinberg for probes, J. Shih for advice on transplantation, M. Selleck and C. LaBonne for advice on bead experiments, and A. Collazo, C. Krull, C. LaBonne, A. Louie, E. Krider, J. Shih, P. Sternberg, B. Wold, K. Zinn, and two anonymous reviewers for comments. Supported by grants from the Beckman Institute and by a National Institute of Mental Health Silvio Conte Center award.
Funding AgencyGrant Number
Caltech Beckman InstituteUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Issue or Number:5323
Record Number:CaltechAUTHORS:20141203-075648501
Persistent URL:
Official Citation:Specification of the Zebrafish Nervous System by Nonaxial Signals Katherine Woo and Scott E. Fraser Science 11 July 1997: 277 (5323), 254-257. [DOI:10.1126/science.277.5323.254]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52299
Deposited By: Tony Diaz
Deposited On:03 Dec 2014 21:03
Last Modified:10 Nov 2021 19:24

Repository Staff Only: item control page