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Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα_(13) Deficiency

Offermanns, Stefan and Mancino, Valeria and Revel, Jean-Paul and Simon, Melvin I. (1997) Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα_(13) Deficiency. Science, 275 (5299). pp. 533-536. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141203-082740702

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Abstract

Heterotrimeric GTP-binding proteins (G proteins) participate in cellular signaling and regulate a variety of physiological processes. Disruption of the gene encoding the G protein subunit α_(13) (Gα_(13)) in mice impaired the ability of endothelial cells to develop into an organized vascular system, resulting in intrauterine death. In addition, Gα_(13) (−/−) embryonic fibroblasts showed greatly impaired migratory responses to thrombin. These results demonstrate that Gα_(13) participates in the regulation of cell movement in response to specific ligands, as well as in developmental angiogenesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.275.5299.533DOIArticle
http://www.sciencemag.org/content/275/5299/533PublisherArticle
Alternate Title:Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency
Additional Information:© 1997 American Association for the Advancement of Science. Received 9 September 1996; accepted 2 December 1996. We thank J. Edens, Y.-H. Hu, and the La Jolla Cancer Research Foundation for technical assistance; T. Gridley for ES cell line CJ7; and A. Aragay, S. Pease, H. Wang, T. Wieland, and J. T. Yang for helpful suggestions. Supported by NIH grants GM 34236 and AG 12288 (M.I.S.). S.O. was a recipient of a fellowship from the Deutsche Forschungsgemeinschaft and the Guenther Foundation.
Funders:
Funding AgencyGrant Number
NIHGM 34236
NIHAG 12288
Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
Guenther FoundationUNSPECIFIED
Issue or Number:5299
Record Number:CaltechAUTHORS:20141203-082740702
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141203-082740702
Official Citation:Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency Stefan Offermanns, Valeria Mancino, Jean-Paul Revel, and Melvin I. Simon Science 24 January 1997: 275 (5299), 533-536. [DOI:10.1126/science.275.5299.533]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52303
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Dec 2014 18:03
Last Modified:03 Oct 2019 07:41

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