Offermanns, Stefan and Mancino, Valeria and Revel, Jean-Paul and Simon, Melvin I. (1997) Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα_(13) Deficiency. Science, 275 (5299). pp. 533-536. ISSN 0036-8075. doi:10.1126/science.275.5299.533. https://resolver.caltech.edu/CaltechAUTHORS:20141203-082740702
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Abstract
Heterotrimeric GTP-binding proteins (G proteins) participate in cellular signaling and regulate a variety of physiological processes. Disruption of the gene encoding the G protein subunit α_(13) (Gα_(13)) in mice impaired the ability of endothelial cells to develop into an organized vascular system, resulting in intrauterine death. In addition, Gα_(13) (−/−) embryonic fibroblasts showed greatly impaired migratory responses to thrombin. These results demonstrate that Gα_(13) participates in the regulation of cell movement in response to specific ligands, as well as in developmental angiogenesis.
| Item Type: | Article | ||||||||||
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| Alternate Title: | Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency | ||||||||||
| Additional Information: | © 1997 American Association for the Advancement of Science. Received 9 September 1996; accepted 2 December 1996. We thank J. Edens, Y.-H. Hu, and the La Jolla Cancer Research Foundation for technical assistance; T. Gridley for ES cell line CJ7; and A. Aragay, S. Pease, H. Wang, T. Wieland, and J. T. Yang for helpful suggestions. Supported by NIH grants GM 34236 and AG 12288 (M.I.S.). S.O. was a recipient of a fellowship from the Deutsche Forschungsgemeinschaft and the Guenther Foundation. | ||||||||||
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| Issue or Number: | 5299 | ||||||||||
| DOI: | 10.1126/science.275.5299.533 | ||||||||||
| Record Number: | CaltechAUTHORS:20141203-082740702 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141203-082740702 | ||||||||||
| Official Citation: | Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα13 Deficiency Stefan Offermanns, Valeria Mancino, Jean-Paul Revel, and Melvin I. Simon Science 24 January 1997: 275 (5299), 533-536. [DOI:10.1126/science.275.5299.533] | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 52303 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | Tony Diaz | ||||||||||
| Deposited On: | 03 Dec 2014 18:03 | ||||||||||
| Last Modified: | 10 Nov 2021 19:24 |
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