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Drosophila drop-dead mutations accelerate the time course of age-related markers

Rogina, Blaka and Benzer, Seymour and Helfand, Stephen L. (1997) Drosophila drop-dead mutations accelerate the time course of age-related markers. Proceedings of the National Academy of Sciences of the United States of America, 94 (12). pp. 6303-6306. ISSN 0027-8424. PMCID PMC21044. https://resolver.caltech.edu/CaltechAUTHORS:20141203-085731718

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Abstract

Mutations of the drop-dead gene in Drosophila melanogaster lead to striking early death of the adult animal. At different times, after emergence from the pupa, individual flies begin to stagger and, shortly thereafter, die. Anatomical examination reveals gross neuropathological lesions in the brain. The life span of flies mutant for the drop-dead gene is four to five times shorter than for normal adults. That raises the question whether loss of the normal gene product might set into motion a series of events typical of the normal aging process. We used molecular markers, the expression patterns of which, in normal flies, change with age in a manner that correlates with life span. In the drop-dead mutant, there is an acceleration in the temporal pattern of expression of these age-related markers.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.94.12.6303 DOIArticle
http://www.pnas.org/content/94/12/6303PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21044/PubMed CentralArticle
Additional Information:© 1997 by The National Academy of Sciences. Contributed by Seymour Benzer, April 4, 1997. We are grateful to Joseph Jack, Deborah Foster, William Orr, Robert Reenan, Marvin Tanzer, and members of the Benzer laboratory for helpful discussions and critical reading of the manuscript. This work was supported by a fellowship to B.R. from The Donaghue Medical Research Foundation, the Sandoz Foundation for Gerontological Research, and the National Institute of Aging-supported Claude Pepper Older Americans Independence Center at the Travelers Center on Aging of the University of Connecticut Health Center, by grants to S.L.H. from the National Science Foundation (IBN- 9122097), the American Federation for Aging Research, the Sandoz Foundation for Gerontological Research, and the Shock Aging Research Foundation. Support to S.B. was from the National Science Foundation (MCB 9408718), the National Institutes of Health (AG 12289 and EY 09278), the McKnight Foundation, and the James G. Boswell Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked ‘‘advertisement’’ in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Donaghue Medical Research FoundationUNSPECIFIED
Sandoz Foundation for Gerontological ResearchUNSPECIFIED
National Institute of AgingUNSPECIFIED
NSFIBN-9122097
American Federation for Aging ResearchUNSPECIFIED
Shock Aging Research FoundationUNSPECIFIED
NSFMCB 9408718
NIHAG 12289
NIHEY 09278
McKnight FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Issue or Number:12
PubMed Central ID:PMC21044
Record Number:CaltechAUTHORS:20141203-085731718
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141203-085731718
Official Citation:Blanka Rogina, Seymour Benzer, and Stephen L. Helfand Drosophila drop-dead mutations accelerate the time course of age-related markers PNAS 1997 94 (12) 6303-6306
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52308
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Dec 2014 20:43
Last Modified:03 Oct 2019 07:41

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