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Electron-tunneling pathways in proteins

Beratan, David N. and Onuchic, José Nelson and Winkler, Jay R. and Gray, Harry B. (1992) Electron-tunneling pathways in proteins. Science, 258 (5089). pp. 1740-1741. ISSN 0036-8075. doi:10.1126/science.1334572.

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Electron-transfer (ET) reactions are key steps in photosynthesis, respiration, drug metabolism, and many other biochemical processes. These ET processes commonly occur between protein-bound prosthetic groups that are separated by large molecular distances (often greater than 10 Å. Although the electron donors and acceptors in these reactions are expected to be weakly coupled, the ETs are remarkably fast and proceed with high specificity. On page 1748 of this issue, Pelletier and Kraut (1) present work on the crystal structures of cytochrome c-cytochrome c peroxidase complexes that could lead to a much deeper understanding of how the intervening medium controls interprotein ET reactions.

Item Type:Article
Related URLs:
URLURL TypeDescription
Winkler, Jay R.0000-0002-4453-9716
Gray, Harry B.0000-0002-7937-7876
Additional Information:© 1992 American Association for the Advancement of Science. We thank J. Regan for assistance in the pathway calculations and preparation of Fig. 2. Supported by the National Science Foundation, the National Institutes of Health, the Department of Energy, and the Arnold and Mabel Beckman Foundation.
Funding AgencyGrant Number
Department of Energy (DOE)UNSPECIFIED
Arnold and Mabel Beckman FoundationUNSPECIFIED
Issue or Number:5089
Record Number:CaltechAUTHORS:20141205-110550464
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Official Citation:Electron-tunneling pathways in proteins DN Beratan, JN Onuchic, Winkler JR, and HB Gray Science 11 December 1992: 258 (5089), 1740-1741. [DOI:10.1126/science.1334572]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52434
Deposited By: Tony Diaz
Deposited On:09 Dec 2014 22:45
Last Modified:10 Nov 2021 19:40

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