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Distinct Mechanisms for Synchronization and Temporal Patterning of Odor-Encoding Neural Assemblies

MacLeod, Katrina and Laurent, Gilles (1996) Distinct Mechanisms for Synchronization and Temporal Patterning of Odor-Encoding Neural Assemblies. Science, 274 (5289). pp. 976-979. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20141208-092950006

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Abstract

Stimulus-evoked oscillatory synchronization of neural assemblies and temporal patterns of neuronal activity have been observed in many sensory systems, such as the visual and auditory cortices of mammals or the olfactory system of insects. In the locust olfactory system, single odor puffs cause the immediate formation of odor-specific neural assemblies, defined both by their transient synchronized firing and their progressive transformation over the course of a response. The application of an antagonist of ionotropic γ-aminobutyric acid (GABA) receptors to the first olfactory relay neuropil selectively blocked the fast inhibitory synapse between local and projection neurons. This manipulation abolished the synchronization of the odor-coding neural ensembles but did not affect each neuron's temporal response patterns to odors, even when these patterns contained periods of inhibition. Fast GABA-mediated inhibition, therefore, appears to underlie neuronal synchronization but not response tuning in this olfactory system. The selective desynchronization of stimulus-evoked oscillating neural assemblies in vivo is now possible, enabling direct functional tests of their significance for sensation and perception.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.274.5289.976 DOIArticle
http://www.sciencemag.org/content/274/5289/976PublisherArticle
http://www.jstor.org/stable/2891299JSTORArticle
ORCID:
AuthorORCID
Laurent, Gilles0000-0002-2296-114X
Additional Information:© 1996 American Association for the Advancement of Science. Received 6 June 1996; accepted 19 September 1996. Supported by a NSF grant and Presidential Faculty Fellow Award to G.L. We thank E. M. Schuman, N. Kopell, and members of the Laurent lab for helpful discussions and comments.
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Record Number:CaltechAUTHORS:20141208-092950006
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141208-092950006
Official Citation:Distinct Mechanisms for Synchronization and Temporal Patterning of Odor-Encoding Neural Assemblies Katrina MacLeod and Gilles Laurent Science 8 November 1996: 274 (5289), 976-979. [DOI:10.1126/science.274.5289.976]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52457
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Dec 2014 22:19
Last Modified:20 Nov 2015 18:43

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