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Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs

De Schutter, Erik and Bower, James M. (1994) Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proceedings of the National Academy of Sciences of the United States of America, 91 (11). pp. 4736-4740. ISSN 0027-8424. PMCID PMC43863. https://resolver.caltech.edu/CaltechAUTHORS:20141208-105205093

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Abstract

Cerebellar Purkinje cell responses to granule cell synaptic inputs were examined with a computer model including active dendritic conductances. Dendritic P-type Ca^2+ channels amplified postsynaptic responses when the model was firing at a physiological rate. Small synchronous excitatory inputs applied distally on the large dendritic tree resulted in somatic responses of similar size to those generated by more proximal inputs. In contrast, in a passive model the somatic postsynaptic potentials to distal inputs were 76% smaller. The model predicts that the somatic firing response of Purkinje cells is relatively insensitive to the exact dendritic location of synaptic inputs. We describe a mechanism of Ca^2+-mediated synaptic amplification, based on the subspiking threshold recruitment of P-type Ca^2+ channels in the dendritic branches surrounding the input site.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1073/pnas.91.11.4736DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc43863/PubMed CentralArticle
Additional Information:© 1994 National Academy of Sciences. Communicated by John J. Hopfield, February 3, 1994. We thank M. Rapp, I. Segev, and Y. Yarom for reconstruction of the Purkinje cell and D. Jaeger and B. Mel for fruitful discussions. This research used the Intel Touchstone Delta System operated by California Institute of Technology on behalf of the Concurrent Supercomputing Consortium; U. S. Bhalla, D. Bilitch, and M. D. Speight helped in porting GENESIS to the Delta; and J. Leigh wrote the visualization software. E.D.S. was supported by Fogarty Fellowship F05 TW04368 (National Institutes of Health), and J.M.B. was supported by grants from the National Science Foundation (NS31378) and the National Institute of Neurological Disorders and Stroke (BIR-9017153). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
NIH Postdoctoral FellowshipF05 TW04368
NIHNS31378
NSFBIR-9017153
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Subject Keywords:cerebelium; amplification; parallel fiber; calcium channel; model
Issue or Number:11
PubMed Central ID:PMC43863
Record Number:CaltechAUTHORS:20141208-105205093
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141208-105205093
Official Citation:De Schutter, E., & Bower, J. M. (1994). Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proceedings of the National Academy of Sciences, 91(11), 4736-4740.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52469
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:08 Dec 2014 20:45
Last Modified:04 Jun 2020 19:52

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