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Repeated fMRI Using Iron Oxide Contrast Agent in Awake, Behaving Macaques at 3 Tesla

Leite, Francisca P. and Tsao, Doris and Vanduffel, Wim and Fize, Denis and Sasaki, Yuka and Wald, Larry L. and Dale, Anders M. and Kwong, Ken K. and Orban, Guy A. and Rosen, Bruce R. and Tootell, Roger B. H. and Mandeville, Joseph B. (2002) Repeated fMRI Using Iron Oxide Contrast Agent in Awake, Behaving Macaques at 3 Tesla. NeuroImage, 16 (2). pp. 283-294. ISSN 1053-8119. https://resolver.caltech.edu/CaltechAUTHORS:20141210-154633692

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Abstract

Iron oxide contrast agents have been employed extensively in anesthetized rodents to enhance fMRI sensitivity and to study the physiology of cerebral blood volume (CBV) in relation to blood oxygen level-dependent (BOLD) signal following neuronal activation. This study quantified the advantages of exogenous agent for repeated neuroimaging in awake, nonhuman primates using a clinical 3 Tesla scanner. A monocrystalline iron oxide nanoparticle (MION) solution was injected at iron doses of 8 to 10 mg/kg in two macaque monkeys. Adverse behavioral effects due to contrast agent were not observed in either monkey using cumulative doses in excess of 60 mg/kg. Relative to BOLD imaging at 3 Tesla, MION increased functional sensitivity by an average factor of 3 across the brain for a stimulus of long duration. Rapid stimulus presentation attenuated MION signal changes more than BOLD signal changes, due to the slower time constant of the blood volume response relative to BOLD signal. Overall, the contrast agent produced a dramatic improvement in functional brain imaging results in the awake, behaving primate at this field strength.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1006/nimg.2002.1110DOIArticle
http://www.sciencedirect.com/science/article/pii/S1053811902911109PublisherArticle
Additional Information:© 2002 Elsevier Science (USA) All rights reserved. Received October 8, 2001 The authors gratefully acknowledge financial support from the National Foundation for Functional Brain Imaging (U.S.A.), from the National Institutes of Health (J.B.M.: R01-RR14543A02; A.M.D.: R01-RR13609, P41-RR14075, R01-NS39581), from the Queen Elisabeth Medical Foundation (GSKE), and from the Flemish Regional Ministry of Education (G.A.O.: GOA 2000/11).
Funders:
Funding AgencyGrant Number
National Foundation for Functional Brain Imaging (U.S.A.)UNSPECIFIED
NIHR01-RR14543A02
NIHR01-RR13609
NIHP41-RR14075
NIHR01-NS39581
Queen Elisabeth Medical Foundation (GSKE)UNSPECIFIED
Flemish Regional Ministry of EducationG.A.O.: GOA 2000/11
Issue or Number:2
Record Number:CaltechAUTHORS:20141210-154633692
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141210-154633692
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52569
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:11 Dec 2014 21:18
Last Modified:03 Oct 2019 07:43

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