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Digital pathology with Fourier ptychography

Horstmeyer, Roarke and Ou, Xiaoze and Zheng, Guoan and Willems, Phil and Yang, Changhuei (2015) Digital pathology with Fourier ptychography. Computerized Medical Imaging and Graphics, 42 . pp. 38-43. ISSN 0895-6111. PMCID PMC4369155.

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Fourier ptychographic microscopy (FPM) is a recently introduced method of acquiring high-resolution, wide field of view (FOV) giga-pixel histology images. The FPM procedure first acquires a sequence of low-resolution images of a sample under variable-angle illumination. It then combines these images using a novel phase retrieval algorithm to improve the employed microscope's resolution beyond its conventional limit. Here, we first describe how FPM's resolution improvement can enhance wide FOV histology imaging. Second, we show that FPM also records a thin sample's optical phase, which can help pathologists digitally extract as much information as possible from a given histology slide.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Horstmeyer, Roarke0000-0002-2480-9141
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2014 Elsevier Ltd. Received 27 March 2014; Received in revised form 28 May 2014; accepted 10 November 2014. We acknowledge funding support from the National Institutes of Health 1DP2OD007307-01 and Clearbridge Biophotonics (Singapore).
Funding AgencyGrant Number
Clearbridge BiophotonicsUNSPECIFIED
Subject Keywords:Digital pathology; Computational imaging; Structured illumination; Super-resolution; Microscopy
PubMed Central ID:PMC4369155
Record Number:CaltechAUTHORS:20141211-154256164
Persistent URL:
Official Citation:Roarke Horstmeyer, Xiaoze Ou, Guoan Zheng, Phil Willems, Changhuei Yang, Digital pathology with Fourier ptychography, Computerized Medical Imaging and Graphics, Volume 42, June 2015, Pages 38-43, ISSN 0895-6111, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52607
Deposited By: Jason Perez
Deposited On:12 Dec 2014 00:19
Last Modified:09 Mar 2020 13:19

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