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On-Chip Fluorescence Microscopy for Wide Field-of-View High-Throughput Phynotype Screening of Caenorhabditis elegans

Han, Chao and Pang, Shuo and Kato, Mihoko and Sternberg, Paul and Yang, Changhuei (2013) On-Chip Fluorescence Microscopy for Wide Field-of-View High-Throughput Phynotype Screening of Caenorhabditis elegans. In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences. , pp. 257-259. ISBN 978-0-9798064-6-9. https://resolver.caltech.edu/CaltechAUTHORS:20141212-093902623

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Abstract

We developed a low-cost compact on-chip fluorescence imaging platform, termed the Fluorescence Talbot Microscopy (FTM), which utilizes the Talbot self-imaging effect to enable efficient fluorescence imaging over a large and directly-scalable field-of-view (FOV). The FTM prototype has a resolution of 1.2 μm and an FOV of 3.9×3.5mm^2. We demonstrate the use of the FTM prototype in performing high-throughput imaging of live Caenorhabditis elegans (C. elegans), and RNA interference (RNAi) phenotyping of distal tip cell (DTC) migration defects in C. elegans.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://www.smart-systems-integration.org/public/news-events/events/microtas-2013OrganizationConference Website
ORCID:
AuthorORCID
Kato, Mihoko0000-0003-3827-8879
Sternberg, Paul0000-0002-7699-0173
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2013 CBMS. This project is funded by National Institute of Health under Grant No. 1R01AI09622601.
Funders:
Funding AgencyGrant Number
NIH1R01AI09622601
Subject Keywords:on-chip fluorescence microscopy, wide field-of-view, Caenorhabditis elegans
Record Number:CaltechAUTHORS:20141212-093902623
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141212-093902623
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52622
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2014 18:06
Last Modified:29 Oct 2019 21:54

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