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A Handheld Magnetic Sensing Platform for Antigen And Nucleic Acid Detection

Pai, A. and Khachaturian, A. and Chapman, S. and Hu, A. and Wang, H. and Hajimiri, A. (2013) A Handheld Magnetic Sensing Platform for Antigen And Nucleic Acid Detection. In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences. , pp. 678-680. ISBN 978-0-9798064-6-9.

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The core requirements for point-of-care (POC) diagnostics necessitate low-cost, high multiplexing, portability, easily integrated sample preparation, and quick measurement time [1, 2]. Frequency-shift based magnetic sensing is a measurement technique utilizing a complementary metal-oxide-semiconductor (CMOS) integrated-circuit (IC) chip for magnetic label detection. Using this technology, we have developed a complete handheld, low-power, low-cost, disposable cartridge-based diagnostic device (Fig. 1a,b) with two fully implemented assays for antigens and nucleic acids. We have demonstrated reliable measurements down to 100 pM for a 31 base-pair oligomer and 1 pM for the protein interferon-γ (IFN-γ).

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Khachaturian, A.0000-0001-8304-3302
Hajimiri, A.0000-0001-6736-8019
Additional Information:© 2013 CBMS. The authors would like to acknowledge Stephanie Johnson and Rob Phillips for their help in aiding DNA attachment chemistry; Habib Ahmad, Alex Sutherland and James Heath for guidance and tools in developing surface chemistry; Derek Rinderknecht and Morteza Gharib for providing high power microscopes; and members of the Caltech CHIC lab for general guidance. This research was supported by the Caltech CI2 and City of Hope grants.
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Caltech CI2 grantUNSPECIFIED
Record Number:CaltechAUTHORS:20141212-101836648
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52623
Deposited By: Tony Diaz
Deposited On:12 Dec 2014 18:40
Last Modified:09 Mar 2020 13:18

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