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Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl

Yoon, Charles H. and Lee, Junho and Jongeward, Gregg D. and Sternberg, Paul W. (1995) Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science, 269 (5227). pp. 1102-1105. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141212-124138923

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Abstract

Vulval induction during Caenorhabditis elegans development is mediated by LET-23, a homolog of the mammalian epidermal growth factor receptor tyrosine kinase. The sli-1 gene is a negative regulator of LET-23 and is shown here to encode a protein similar to c-Cbl, a mammalian proto-oncoprotein. SLI-1 and c-Cbl share approximately 55 percent amino acid identity over a stretch of 390 residues, which includes a C_3HC_4 zinc-binding motif known as the RING finger, and multiple consensus binding sites for Src homology 3 (SH3) domains. SLI-1 and c-Cbl may define a new class of proteins that modify receptor tyrosine kinase-mediated signal transduction.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7652556DOIArticle
http://www.sciencemag.org/content/269/5227/1102.abstractPublisherArticle
http://www.jstor.org/stable/2888053JSTORArticle
ORCID:
AuthorORCID
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 1995 American Association for the Advancement of Science. Received 13 April 1995; accepted 2 June 1995. We thank G. Lesa, N. Hopper, and R. Sommer for comments on the manuscript; G. Medina and other members of the Sternberg laboratory for technical assistance; J. Mendel for pJMG3BP.11; and W. Langdon for discussions. Supported by a grant from the U.S. Public Health Service to P.W.S., who is an investigator with the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)UNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5227
Record Number:CaltechAUTHORS:20141212-124138923
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141212-124138923
Official Citation:Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl CH Yoon, J Lee, GD Jongeward, and PW Sternberg Science 25 August 1995: 269 (5227), 1102-1105. [DOI:10.1126/science.7652556]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52632
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2014 20:59
Last Modified:03 Mar 2020 13:01

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