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Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

Kang, Hyejin and Schuman, Erin M. (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science, 267 (5204). pp. 1658-1662. ISSN 0036-8075. doi:10.1126/science.7886457. https://resolver.caltech.edu/CaltechAUTHORS:20141212-133457994

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Abstract

The neurotrophins are signaling factors important for the differentiation and survival of distinct neuronal populations during development. To test whether the neurotrophins also function in the mature nervous system, the effects of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophic factor 3 (NT-3) on the strength of synaptic transmission in hippocampal slices were determined. Application of BDNF or NT-3 produced a dramatic and sustained (2 to 3 hours) enhancement of synaptic strength at the Schaffer collateral-CA1 synapses; NGF was without significant effect. The enhancement was blocked by K252a, an inhibitor of receptor tyrosine kinases. BDNF and NT-3 decreased paired-pulse facilitation, which is consistent with a possible presynaptic modification. Long-term potentiation could still be elicited in slices previously potentiated by exposure to the neurotrophic factors, which implies that these two forms of plasticity may use at least partially independent cellular mechanisms.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.7886457 DOIArticle
http://www.sciencemag.org/content/267/5204/1658PublisherArticle
http://www.jstor.org/stable/2886751JSTORArticle
ORCID:
AuthorORCID
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 1995 American Association for the Advancement of Science. Received 27 October 1994; accepted 10 February 1995. We thank D. Anderson, M. Kennedy, G. Laurent, P. Patterson, and members of the Schuman lab for helpful discussions and comments and C. Hung for writing data acquisition and analysis software. We thank Amgen for supplying BDNF and NT-3. E.S. is a John Merck Scholar and an Alfred P. Sloan Fellow.
Funders:
Funding AgencyGrant Number
John Merck FundUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:5204
DOI:10.1126/science.7886457
Record Number:CaltechAUTHORS:20141212-133457994
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141212-133457994
Official Citation:Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus H Kang and EM Schuman Science 17 March 1995: 267 (5204), 1658-1662. [DOI:10.1126/science.7886457]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52771
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2014 22:23
Last Modified:10 Nov 2021 19:43

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