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The Structures of BtuCD and MscS and their Implications for Transporter and Channel Function

Bass, Randal B. and Locher, Kaspar P. and Borths, Elizabeth and Poon, Yan and Strop, Pavel and Lee, Allen and Rees, Douglas C. (2003) The Structures of BtuCD and MscS and their Implications for Transporter and Channel Function. FEBS Letters, 555 (1). pp. 111-115. ISSN 0014-5793. https://resolver.caltech.edu/CaltechAUTHORS:20141212-144942986

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Abstract

The passage of most molecules across biological membranes is mediated by specialized integral membrane proteins known as channels and transporters. Although these transport families encompass a wide range of functions, molecular architectures and mechanisms, there are common elements that must be incorporated within their structures, namely the translocation pathway, ligand specificity elements and regulatory sensors to control the rate of ligand £ow across the membrane. This minireview discusses aspects of the structure and mechanism of two bacterial transport systems, the stretch-activated mechanosensitive channel of small conductance (MscS) and the ATP-dependent vitamin B12 uptake system (BtuCD), emphasizing their general implications for transporter function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0014-5793(03)01126-8DOIArticle
http://www.sciencedirect.com/science/article/pii/S0014579303011268PublisherArticle
ORCID:
AuthorORCID
Rees, Douglas C.0000-0003-4073-1185
Contact Email Address:phoebe@caltech.edu
Additional Information:© 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Received 25 August 2003; accepted 1 September 2003 Research in the authors’ lab was supported in part by the US National Institutes of Health, grant GM62532, to D.C.R. and a postdoctoral fellowship to R.B.B.
Funders:
Funding AgencyGrant Number
NIHGM62532
Subject Keywords:Transport protein; Mechanosensitive channel; ATP binding cassette transporter; Membrane protein structure
Issue or Number:1
Record Number:CaltechAUTHORS:20141212-144942986
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141212-144942986
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52784
Collection:CaltechAUTHORS
Deposited By: SWORD User
Deposited On:22 Dec 2014 20:57
Last Modified:03 Oct 2019 07:44

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