Strop, Pavel and Bass, Randal and Rees, Douglas C. (2003) Prokaryotic Mechanosensitive Channels. In: Membrane Proteins. Advances in Protein Chemistry. No.63. Elsevier , New York, NY, pp. 177-209. ISBN 978-0-12-034263-1. https://resolver.caltech.edu/CaltechAUTHORS:20141212-145528968
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20141212-145528968
Abstract
Mechanosensitive ion channels are integral membrane proteins that open and close in response to mechanical stress applied either directly to the cell membrane (in the case of intrinsically mechanosensitive channels) or indirectly, through forces applied to other cytoskeletal components. Cellular phenomena mediated by mechanosensitive channels include touch, hearing, cardiovascular tone, detection of gravity, pressure sensation, pain perception, and osmoregulation. Mechanosensirive channels are quite diverse both physiologically and structurally and have been discovered in all fundamental branches of the phylogenetic tree, Eubacteria, Eukarya, and Archaea. Eukaryotic mechanosensitive channels include the TRPV subclass of the Transient Receptor Potential channel family: the TREK-1 and TRAAK members of the two-pore domain potassium channel family K2p; and the DEG/ENaC superfamily composed of degenerins, eptithelial sodium channels, and acid-sensing channels that have been implicated in the touch response of nematodes. Although many of these channels, including the degenerins and the yet-to-be identified channel receptors involved in hearing, appear to have an obligatory requirement for cytoskeletal coupling, others, such as the TREK-1 and TRAAK channels, exhibit intrisinic mechanosensitive activity.
Item Type: | Book Section | ||||||||
---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||
ORCID: |
| ||||||||
Contact Email Address: | phoebe@caltech.edu | ||||||||
Additional Information: | © 2003 Elsevier. Discussions with Sidney Wang, Meg Barclay, Rober Spencer, Kaspar Locher, Geoffrey Chang, Dennis Dougherty, Henry Lester, Rob Phillips, and Eduardo Perozo are greatly appreciated. This work was supported in part by NIH grants GM62532 to D.C.R. and GM20705 to R.B.B. | ||||||||
Funders: |
| ||||||||
Series Name: | Advances in Protein Chemistry | ||||||||
Issue or Number: | 63 | ||||||||
DOI: | 10.1016/S0065-3233(03)63008-1 | ||||||||
Record Number: | CaltechAUTHORS:20141212-145528968 | ||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141212-145528968 | ||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
ID Code: | 52789 | ||||||||
Collection: | CaltechAUTHORS | ||||||||
Deposited By: | SWORD User | ||||||||
Deposited On: | 22 Dec 2014 19:54 | ||||||||
Last Modified: | 10 Nov 2021 19:43 |
Repository Staff Only: item control page