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Engineered metal-binding proteins: purification to protein folding

Arnold, Frances H. and Haymore, Barry L. (1991) Engineered metal-binding proteins: purification to protein folding. Science, 252 (5014). pp. 1796-1797. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141215-105527216

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Abstract

Proteins can make use of metal ions to bind substrates, to maintain structure, to effect catalysis, and for allosteric control and regulation. In order to hold a particular metal ion with high affinity and specificity, proteins form multidentate binding pockets designed to fulfill both the chemical and geometric bonding requirements of that metal. Metal recognition can be engineered into proteins for applications such as protein purification.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1648261 DOIArticle
http://www.sciencemag.org/content/252/5014/1796PublisherArticle
http://www.jstor.org/stable/2875870JSTORArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1991 American Association for the Advancement of Science. We thank G. Wuenschell, R. Todd, S.-S. Suh, J. Kellis, R. Lcimgruber, G. Bild, and G. Krivi fur their contributions to this work. Support from Monsanto Company, the National Science Foundation, and the Office of Naval Research and a fellowship from the David and Lucile Packard Foundation are gratefully acknowledged (F.H.A.).
Funders:
Funding AgencyGrant Number
Monsanto CompanyUNSPECIFIED
NSFUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Issue or Number:5014
Record Number:CaltechAUTHORS:20141215-105527216
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141215-105527216
Official Citation:Engineered metal-binding proteins: purification to protein folding FH Arnold and BL Haymore Science 28 June 1991: 252 (5014), 1796-1797. [DOI:10.1126/science.1648261]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52811
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Dec 2014 20:29
Last Modified:03 Oct 2019 07:44

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