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Locally distributed synaptic potentiation in the hippocampus

Schuman, Erin M. and Madison, Daniel V. (1994) Locally distributed synaptic potentiation in the hippocampus. Science, 263 (5146). pp. 532-536. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20141216-122504273

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Abstract

The long-lasting increase in synaptic strength known as long-term potentiation has been advanced as a potential physiological mechanism for many forms of both developmental and adult neuronal plasticity. In many models of plasticity, intercellular communication has been proposed to account for observations in which simultaneously active neurons are strengthened together. The data presented here indicate that long-term potentiation can be communicated between synapses on neighboring neurons by means of a diffusible messenger. This distributed potentiation provides a mechanism for the cooperative strengthening of proximal synapses and may underlie a variety of plastic processes in the nervous system.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.8290963DOIArticle
http://www.sciencemag.org/content/263/5146/532PublisherArticle
http://www.jstor.org/stable/2883037JSTORArticle
ORCID:
AuthorORCID
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 1994 American Association for the Advancement of Science. 19 July 1993; Accepted 29 November 1993. We thank E. Schaible and I. Parada for technical assistance. We also thank J. Haley, T. Schwarz, and C. Shatz for comnments on this manuscript.
Issue or Number:5146
Record Number:CaltechAUTHORS:20141216-122504273
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141216-122504273
Official Citation:Schuman, E. M., & Madison, D. V. (1994). Locally distributed synaptic potentiation in the hippocampus. Science, 263(5146), 532-536.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52871
Collection:CaltechAUTHORS
Deposited By: Joanne McCole
Deposited On:16 Dec 2014 20:50
Last Modified:09 Mar 2020 13:19

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