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Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA

Normanly, Jennifer and Ollick, Tracy and Abelson, John (1992) Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA. Proceedings of the National Academy of Sciences of the United States of America, 89 (12). pp. 5680-5684. ISSN 0027-8424. https://resolver.caltech.edu/CaltechAUTHORS:20141216-141202011

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Abstract

Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.89.12.5680DOIArticle
http://www.pnas.org/content/89/12/5680.abstractPublisherArticle
Additional Information:© National Academy of Sciences. Contributed by John Abelson, February 26, 1992. We acknowledge with thanks the perceptive advice of Margaret Saks and Jeffrey Sampson in preparation of the manuscript. We also thank Haul Wong and David Teplow of the California Institute of Technology Microchemical Facility and Lynn Williams and Jolene Omiya of the University of Southern California Core Microchemical Laboratory for protein sequencing. This research was supported by grants from Office of Naval Research (N00014-86-K-0755) and National Institutes of Health (GM32637).
Funders:
Funding AgencyGrant Number
Office of Naval Research (ONR)N00014-86-K-0755
NIHGM32637
Issue or Number:12
Record Number:CaltechAUTHORS:20141216-141202011
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141216-141202011
Official Citation:Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA. J Normanly, T Ollick, and J Abelson PNAS 1992 89 (12) 5680-5684; doi:10.1073/pnas.89.12.5680
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52889
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 Dec 2014 22:21
Last Modified:03 Oct 2019 07:45

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