Normanly, Jennifer and Ollick, Tracy and Abelson, John (1992) Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA. Proceedings of the National Academy of Sciences of the United States of America, 89 (12). pp. 5680-5684. ISSN 0027-8424. PMCID PMC49356. doi:10.1073/pnas.89.12.5680. https://resolver.caltech.edu/CaltechAUTHORS:20141216-141202011
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Abstract
Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.
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| Additional Information: | © National Academy of Sciences. Contributed by John Abelson, February 26, 1992. We acknowledge with thanks the perceptive advice of Margaret Saks and Jeffrey Sampson in preparation of the manuscript. We also thank Haul Wong and David Teplow of the California Institute of Technology Microchemical Facility and Lynn Williams and Jolene Omiya of the University of Southern California Core Microchemical Laboratory for protein sequencing. This research was supported by grants from Office of Naval Research (N00014-86-K-0755) and National Institutes of Health (GM32637). | |||||||||
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| Issue or Number: | 12 | |||||||||
| PubMed Central ID: | PMC49356 | |||||||||
| DOI: | 10.1073/pnas.89.12.5680 | |||||||||
| Record Number: | CaltechAUTHORS:20141216-141202011 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141216-141202011 | |||||||||
| Official Citation: | Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA. J Normanly, T Ollick, and J Abelson PNAS 1992 89 (12) 5680-5684; doi:10.1073/pnas.89.12.5680 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 52889 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 16 Dec 2014 22:21 | |||||||||
| Last Modified: | 10 Nov 2021 19:45 |
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