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Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo

Strecker, Teresa R. and Yip, Man Lun R. and Lipshitz, Howard D. (1991) Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo. Proceedings of the National Academy of Sciences of the United States of America, 88 (13). pp. 5824-5828. ISSN 0027-8424. PMCID PMC51970. doi:10.1073/pnas.88.13.5824.

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The developmental signal that specifies the fates of cells at the anterior and posterior termini of the Drosophila embryo is transmitted by the torso receptor tyrosine kinase. This paper presents the results of a genetic interaction test for zygotic loci that act downstream of torso in the terminal genetic hierarchy. Tests of 26 zygotic mutants with defects in terminal development indicate that at least 14 reside in this hierarchy. The phenotypes associated with these genes fall into three classes, each of which represents a distinct aspect of terminal development and evolution. Four of the genes have been molecularly cloned and their products include an intercellular communication factor and three kinds of transcription factors.

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Additional Information:© 1991 National Academy of Sciences. Communicated by Edward B. Lewis, April 15, 1991 (received for review March 14, 1991). We thank the Bowling Green Drosophila Stock Center, W. Gelbart, T. Schubach, D. Weigel, and E. Wieschaus for providing mutant lines; H. Krause for providing anti-ftz antibodies; V. Pirrotta and W. Gelbart for communicating results prior to publication; S. Parkhurst for advice on and assistance with antibody stains; W. Fisher and L. Richardson for technical assistance; and D. Anderson, E. Davidson, S. Halsell, D. Mathog, S. Parkhurst, P. Sternberg, and K. Zinn for critical comments on the manuscript. T.R.S. was supported by junior and senior postdoctoral fellowships from the American Cancer Society (California Division) (respectively J-49-87 and S-23-89); M.L.R.Y. is supported by a predoctoral fellowship from the Howard Hughes Medical Institute. This research was funded by U.S. Public Health Service Research Grant HD23099 and the Searle Scholars Program of the Chicago Community Trust (both awards to H.D.L.). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funding AgencyGrant Number
American Cancer SocietyJ-49-87
American Cancer SocietyS-23-89
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Searle Scholars ProgramUNSPECIFIED
Chicago Community TrustUNSPECIFIED
Subject Keywords:terminal genes; insect evolution; maternal effect genes; pattern formation; morphogenesis
Issue or Number:13
PubMed Central ID:PMC51970
Record Number:CaltechAUTHORS:20141216-145840672
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Official Citation:Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo. T R Strecker, M L Yip, and H D Lipshitz PNAS 1991 88 (13) 5824-5828; doi:10.1073/pnas.88.13.5824
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:52897
Deposited By: Ruth Sustaita
Deposited On:16 Dec 2014 23:20
Last Modified:10 Nov 2021 19:45

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