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Gut Microbes and the Brain: Paradigm Shift in Neuroscience

Mayer, Emeran A. and Knight, Rob and Mazmanian, Sarkis K. and Cryan, John F. and Tillisch, Kirsten (2014) Gut Microbes and the Brain: Paradigm Shift in Neuroscience. Journal of Neuroscience, 34 (46). pp. 15490-15496. ISSN 0270-6474. PMCID PMC4228144. https://resolver.caltech.edu/CaltechAUTHORS:20141219-132621554

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Abstract

The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. A growing body of preclinical literature has demonstrated bidirectional signaling between the brain and the gut microbiome, involving multiple neurocrine and endocrine signaling mechanisms. While psychological and physical stressors can affect the composition and metabolic activity of the gut microbiota, experimental changes to the gut microbiome can affect emotional behavior and related brain systems. These findings have resulted in speculation that alterations in the gut microbiome may play a pathophysiological role in human brain diseases, including autism spectrum disorder, anxiety, depression, and chronic pain. Ongoing large-scale population-based studies of the gut microbiome and brain imaging studies looking at the effect of gut microbiome modulation on brain responses to emotion-related stimuli are seeking to validate these speculations. This article is a summary of emerging topics covered in a symposium and is not meant to be a comprehensive review of the subject.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.3299-14.2014 DOIArticle
http://www.jneurosci.org/content/34/46/15490PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228144/PubMed CentralArticle
ORCID:
AuthorORCID
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2014 the authors. Beginning six months after publication SfN’s license will be nonexclusive and SfN grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ Received Aug. 8, 2014; revised Oct. 10, 2014; accepted Oct. 10, 2014. This work was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK048351 to E.A.M., Grant P30 DK041301, National Institutes of Health/National Institute of Mental Health Grant R01 MH100556 to S.K.M., Autism Speaks to S.K.M., Simons Foundation SFARI Program to S.K.M., and Howard Hughes Medical Institute to R.K. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
NIHR01 DK048351
NIHP30 DK041301
NIHR01 MH100556
Autism SpeaksUNSPECIFIED
Simons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:46
PubMed Central ID:PMC4228144
Record Number:CaltechAUTHORS:20141219-132621554
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20141219-132621554
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53050
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Dec 2014 21:36
Last Modified:03 Oct 2019 07:46

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