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Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators

Chang, Caren and Kwok, Shing F. and Bleecker, Anthony B. and Meyerowitz, Elliot M. (1993) Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science, 262 (5133). pp. 539-544. ISSN 0036-8075. doi:10.1126/science.8211181.

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Ethylene behaves as a hormone in plants, regulating such aspects of growth and development as fruit ripening, flower senescence, and abscission. Ethylene insensitivity is conferred by dominant mutations in the ETR1 gene early in the ethylene signal transduction pathway of Arabidopsis thaliana. The ETR1 gene was cloned by the method of chromosome walking. Each of the four known etr1 mutant alleles contains a missense mutation near the amino terminus of the predicted protein. Although the sequence of the amino-terminal half of the deduced ETR1 protein appears to be novel, the carboxyl-terminal half is similar in sequence to both components of the prokaryotic family of signal transducers known as the two-component systems. Thus, an early step in ethylene signal transduction in plants may involve transfer of phosphate as in prokaryotic two-component systems. The dominant etr1-1 mutant gene conferred ethylene insensitivity to wild-type Arabidopsis plants when introduced by transformation.

Item Type:Article
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URLURL TypeDescription JSTORArticle
Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1993 American Association for the Advancement of Science. 8 July 1993; Accepted 22 September 1993. We thank J. Hua for carrying out RNA blots and M. Kinnell for assistance with chromosome walking. We thank G Chen for seeds of etrl-2, G Roman and J. Ecker for seeds of etrl-3 and etrl-4, C. Somerville for the YAC library, and 1. Ota and A. Varshavsky for sharing their unpublished results. We thank G. Schaller for helpful discussions and the members of the Meyerowitz lab for critical reading of the manuscript. Supported by Department of Energy grant DE-FGO3-88ER13873 (to E M M.) and a National Science Foundation Plant Postdoctoral Fellowship (to C C.).
Funding AgencyGrant Number
Department of Energy (DOE)DE-FG03-88ER13873
NSF Postdoctoral FellowshipUNSPECIFIED
Issue or Number:5133
Record Number:CaltechAUTHORS:20141222-112309012
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Official Citation:Chang, C., Kwok, S., Bleecker, A., & Meyerowitz, E. (1993). Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science, 262(5133), 539-544. doi: 10.1126/science.8211181
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53089
Deposited By: Joanne McCole
Deposited On:22 Dec 2014 22:37
Last Modified:10 Nov 2021 19:47

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