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Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

Hanafi-Bojd, Mohammad Yahya and Jaafari, Mahmoud Reza and Ramezanian, Navid and Xue, Min and Amin, Mohamadreza and Shahtahmasbi, Nasser and Malaekeh-Nikouei, Bizhan (2015) Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells. European Journal of Pharmaceutics and Biopharmaceutics, 86 . pp. 248-258. ISSN 0939-6411. http://resolver.caltech.edu/CaltechAUTHORS:20141222-130918789

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Abstract

Recent studies with inorganic nanoparticles modified with functional groups have demonstrated improvement in drug delivery into cancer cells. In the present study, we prepared, characterized, and evaluated mesoporous silica nanoparticles (MSNs) as carriers for epirubicin hydrochloride (EPI) in order to improve the antitumor efficacy of this drug. MSNs were prepared and functionalized with phosphonate, polyethylene glycol (PEG) and polyethylenimine–polyethylene glycol (PEI–PEG) groups. Different nanoparticulate formulations were loaded with EPI. The in vitro cytotoxicity and the in vivo antitumor efficacy of MSNs containing EPI were evaluated versus free EPI. The EPI release from nanoparticles was shown to be pH-dependent. The size of MSNs functionalized with polyethyleneimine-polyethylene glycol (MSN–PEI–PEG) was 123.8 ± 4.8 nm. This formulation showed the best antitumor effects at an EPI dose of 9 mg/kg in C-26 colon carcinoma model. The biodistribution results proved that MSN–PEI–PEG–EPI had a higher tumor accumulation compared to free EPI, 3 h after drug administration. The results indicated that this formulation could be effective nanocarriers for anti-tumor therapies.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.ejpb.2014.12.009DOIArticle
http://www.sciencedirect.com/science/article/pii/S0939641114003646PublisherArticle
Additional Information:© 2014 Elsevier B.V. Received 13 October 2014, Accepted 7 December 2014, Available online 13 December 2014. The results described in this paper are extracted from Mohammad Yahya Hanafi-Bojd’s Ph.D. thesis. This study was supported by a Grant from the Vice Chancellor for Research of Mashhad University of Medical Science, Mashhad, Iran.
Funders:
Funding AgencyGrant Number
Mashhad University of Medical Science (Iran)UNSPECIFIED
Subject Keywords:Cancer treatment; Epirubicin; Lyophilization; Mesoporous silica nanoparticles
Record Number:CaltechAUTHORS:20141222-130918789
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141222-130918789
Official Citation:Mohammad Yahya Hanafi-Bojd, Mahmoud Reza Jaafari, Navid Ramezanian, Min Xue, Mohamadreza Amin, Nasser Shahtahmassebi, Bizhan Malaekeh-Nikouei, Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells, European Journal of Pharmaceutics and Biopharmaceutics, Volume 89, January 2015, Pages 248-258, ISSN 0939-6411, http://dx.doi.org/10.1016/j.ejpb.2014.12.009. (http://www.sciencedirect.com/science/article/pii/S0939641114003646)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53097
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:23 Dec 2014 16:44
Last Modified:24 Apr 2015 19:45

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