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Paralysis and Early Death in Cysteine String Protein Mutants of Drosophila

Zinsmaier, Konrad E. and Eberle, Kai K. and Buchner, Erich and Walter, Niklaus and Benzer, Seymour (1994) Paralysis and Early Death in Cysteine String Protein Mutants of Drosophila. Science, 263 (5149). pp. 977-980. ISSN 0036-8075.

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Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.

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Additional Information:© 1994 American Association for the Advancement of Science. Received 16 September 1993; accepted 18 January 1994. We acknowledge the assistance of S. Ou and P. Patterson of the Caltech monoclonal antibody facility in providing the mAbs and E. Schwarz for the Northern blots. The "site-directed P-mutagenesis" was performed by two of us (K.K.E. and N.W.) in the laboratories of E. Hafen and M Noll at the University of Zurich. The technical assistance of M. Jenni, O. Zilian (Zurich), N. Krejci, and Y. Schleger of the Buchner laboratory and R. Young, L. Dowling, C. Pham, and E. Eichenberger of the Benzer laboratory is acknowledged. We thank the other members of the Benzer group for their critical comments on the manuscript. Supported by a fellowship to K.E.Z. and by grants to E.B. from the Deutsche Forschungsgemeinschaft and by grants to S.B. from the NSF, the National Eye Institute of the NIH, and the James G. Boswell Foundation.
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Deutsche Forschungsgemeinschaft (DFG)UNSPECIFIED
National Eye InstituteUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Issue or Number:5149
Record Number:CaltechAUTHORS:20141222-142754308
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Official Citation:Paralysis and early death in cysteine string protein mutants of Drosophila KE Zinsmaier, KK Eberle, E Buchner, N Walter, and S Benzer Science 18 February 1994: 263 (5149), 977-980. [DOI:10.1126/science.8310297]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53112
Deposited By: Tony Diaz
Deposited On:22 Dec 2014 22:39
Last Modified:03 Oct 2019 07:47

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