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Regulation of Gene Expression by Interferons: Control of H-2 Promoter Responses

Korber, Bette and Mermod, Nicolas and Hood, Leroy and Stroynowski, Iwona (1988) Regulation of Gene Expression by Interferons: Control of H-2 Promoter Responses. Science, 239 (4845). pp. 1302-1306. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20141223-084427480

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Abstract

The magnitude of the response to interferons and the requirement for individual elements in the promoter of the H-2Dd gene were shown to be cell-specific and dependent on the type of interferon used. Three DNA sequences in the promoter were found to bind murine nuclear factors. Two of these sequences are in functionally defined enhancer regions and also bind to the transcription factor AP-1. The third sequence is part of the region involved in interferon regulation and is homologous to the enhancer element of the interferon beta gene. A model for interferon regulation of H-2 promoters is discussed.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.3125612DOIArticle
http://www.sciencemag.org/content/239/4845/1302PublisherArticle
http://www.jstor.org/stable/1700896JSTORArticle
Additional Information:© 1988 American Association for the Advancement of Science. Received 25 August 1987; accepted 31 December 1987. We thank K. Blackburn and M. Krempin for superb professional assistance with tissue culture, and D. Bohmann for advice during AP-1 purification. We thank M. Shepard of Genentech for providing the recombinant murine IFN γ, D. Vapnek of AMGen for human α consensus IFN, and T. Hansen for monoclonal antibodies. Supported by a National Research Service Award (T32GM7616) from the National Institute of General Medical Sciences and by an NIH grant AI 19624.
Funders:
Funding AgencyGrant Number
National Institute of General Medical SciencesT32GM7616
NIHAI 19624
Record Number:CaltechAUTHORS:20141223-084427480
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20141223-084427480
Official Citation:Regulation of gene expression by interferons: control of H-2 promoter responses B Korber, N Mermod, L Hood, and I Stroynowski Science 11 March 1988: 239 (4845), 1302-1306. [DOI:10.1126/science.3125612]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53132
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Dec 2014 16:52
Last Modified:23 Dec 2014 16:52

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