Saavedra, Raul A. (1986) Histones and Metal-Binding Domains. Science, 234 (4783). p. 1589. ISSN 0036-8075. doi:10.1126/science.3787266. https://resolver.caltech.edu/CaltechAUTHORS:20141223-101634356
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Abstract
Jeremy M. Berg (1) describes potential metal-binding domains in nucleic acid-binding proteins. These metal-binding domains consist of sequences Cys-X_(2-4)-Cys-X_(4-15)-His-X_(2-8)-Cys. Berg also cites the fact that proteins known to bind ions have short sequences of the form Cys-X_(2-4)-Cys, Cys-X_(2-4)-His, or His-X_(2-3)-His. A well-known DNA-binding protein, histone H3, also has the conserved sequence Cys-Ala-Ile-His from residues 110 to 113 (2). The nucleosome octamer has two histones of each kind of four histones. These histones are organized about an axis of symmetry, such that these conserved sequences on each histone H3 oppose each other (3). The apposition of these two histone H3 sequences would generate a structure potentially able to coordinate a metal ion, namely 2(Cys-Ala-Ile-His).
Item Type: | Article | ||||||||||||
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Additional Information: | © 1986 American Association for the Advancement of Science. Received 20 May 1986; accepted 29 October 1986. | ||||||||||||
Issue or Number: | 4783 | ||||||||||||
DOI: | 10.1126/science.3787266 | ||||||||||||
Record Number: | CaltechAUTHORS:20141223-101634356 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20141223-101634356 | ||||||||||||
Official Citation: | Histones and metal-binding domains RA Saavedra Science 19 December 1986: 234 (4783), 1589. [DOI:10.1126/science.3787266] | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 53142 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Tony Diaz | ||||||||||||
Deposited On: | 23 Dec 2014 18:43 | ||||||||||||
Last Modified: | 10 Nov 2021 19:48 |
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