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Non‐Canonical Amino Acids in Protein Polymer Design

Connor, Rebecca E. and Tirrell, David A. (2007) Non‐Canonical Amino Acids in Protein Polymer Design. Journal of Macromolecular Science, Part C: Polymer Reviews, 47 (1). pp. 9-28. ISSN 1558-3724. doi:10.1080/15583720601109552.

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Protein polymers can be prepared with essentially absolute control of chain length, sequence, and stereochemistry through biological synthesis in microbial hosts. But for the polymer chemist, the twenty “canonical” amino acids provide an unacceptably small set of starting materials for macromolecular design. In the past several years, powerful techniques have been developed to introduce non-natural (non-canonical) amino acids containing a wide variety of functional groups into recombinant proteins. This review presents the methods currently available for the introduction of non-natural amino acids into engineered proteins both in vitro and in vivo. Methods for multiple- and single-site introduction are described. Recent applications of these methods are also addressed, particularly the development of biosensors, novel surfaces, and materials.

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Tirrell, David A.0000-0003-3175-4596
Additional Information:Copyright © Taylor & Francis Group, LLC Received 2 October 2006; Accepted 31 October 2006. Work on non-canonical amino acids at Caltech is supported by NIH grants GM62523 and EB1971, by the NSF Center for Science and Engineering of Materials, by the ARO Institute for Collaborative Biotechnologies, and by the Joseph J. Jacobs Institute for Molecular Engineering for Medicine.
Funding AgencyGrant Number
Army Research Office (ARO)UNSPECIFIED
Joseph J. Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
Subject Keywords:proteins, non-canonical amino acids, biological synthesis, biomaterials, biopolymers
Issue or Number:1
Record Number:CaltechAUTHORS:20150114-132717865
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53242
Deposited By: Anne Hormann
Deposited On:16 Jan 2015 04:38
Last Modified:10 Nov 2021 19:49

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