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Coiled-Coil Peptide-Based Assembly of Gold Nanoparticles

Stevens, Molly M. and Flynn, Nolan T. and Wang, Chun and Tirrell, David A. and Langer, Robert (2004) Coiled-Coil Peptide-Based Assembly of Gold Nanoparticles. Advanced Materials, 16 (11). pp. 915-918. ISSN 0935-9648. http://resolver.caltech.edu/CaltechAUTHORS:20150121-101000800

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Abstract

The ability to direct the assembly of inorganic nanoparticles using biomolecular recognition is of growing interest in the development of new materials and nanotechnology devices.[1,2] Previous studies have described the use of the highly specific biomolecular recognition systems of DNA,[3,4] the streptavidin/biotin system,[5,6] antibody/antigen systems,[7] and a peptide based linker system[8] to direct nanoparticle assembly. The reversibility of the biological assembly process has not been probed in depth for these nanoparticle systems, with the exception of temperature changes to control the assembly of DNA-linked nanoparticles.[3] For certain applications in medical science such as the generation of novel tunable and/or switchable materials potentially useful for sensing in vivo and drug delivery, the ability to dynamically assemble and disassemble such structures when triggered by physiologically accessible environmental conditions such as changes in pH would be valuable.[1,9] Here we report the coiled-coil-based assembly of gold nanoparticles and demonstrate that the system can be controlled under mild conditions (near-neutral pH and ambient temperature). The flexibility in design afforded by varying the peptide sequence to produce coiled coils with different stabilities is also highlighted through the generation of more stable binary nanoparticle systems with controlled spacing and architecture.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/adma.200306430DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/adma.200306430/abstractPublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Received: November 6, 2003 Final version: January 23, 2004 Published online: April 20, 2004 We thank Professor Robert Sauer for the use of the Aviv spectropolarimeter and Jill Sakata for help with the bacterial expression of the peptides. We acknowledge the support of the National Institutes of Health (Grant #DE-13023).
Funders:
Funding AgencyGrant Number
NIHDE-13023
Record Number:CaltechAUTHORS:20150121-101000800
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150121-101000800
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53291
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:21 Jan 2015 19:44
Last Modified:21 Jan 2015 20:26

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