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Location and Chemical Synthesis of a Pre-S Gene Coded Immunodominant Epitope of Hepatitis B Virus

Neurath, A. Robert and Kent, Stephen B. H. and Strick, Nathan (1984) Location and Chemical Synthesis of a Pre-S Gene Coded Immunodominant Epitope of Hepatitis B Virus. Science, 224 (4647). pp. 392-395. ISSN 0036-8075. doi:10.1126/science.6200931.

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Immunodominant, disulfide-bond independent epitopes recognized by human antibodies to hepatitis B virus (HBV) are located within the 55-residue amino terminal portion (coded for by the pre-S region of HBV DNA) of minor HBV envelope components larger than the major protein constituents encoded by the S gene. A peptide having the sequence of the first 26 amino acids from the amino terminal methionine was synthesized and elicited antibodies (at dilutions of greater than or equal to 1 to 10^5) to the HBV envelope. These antibodies can be utilized for diagnostic tests. The immunogenicity of the peptide was substantially increased by covalent attachment to liposomes. The disulfide bond-independent determinants on sequences coded for by the pre-S gene may be more easily mimicked by peptide analogs than "conformational" determinants on the S-gene product.

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Additional Information:© 1984 American Association for the Advancement of Science. Received 6 February 1984; accepted 15 March 1984. We thank T. Huima, P. Sproul, and W. Lee for assistance. Partially supported by National Heart, Lung and Blood Institute grant 09011.
Funding AgencyGrant Number
National Heart, Lung and Blood Institute09011
Issue or Number:4647
Record Number:CaltechAUTHORS:20150107-134728246
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Official Citation:Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus AR Neurath, SB Kent, and N Strick Science 27 April 1984: 224 (4647), 392-395. [DOI:10.1126/science.6200931]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53293
Deposited By: Tony Diaz
Deposited On:08 Jan 2015 02:50
Last Modified:10 Nov 2021 20:00

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