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Location and Chemical Synthesis of a Pre-S Gene Coded Immunodominant Epitope of Hepatitis B Virus

Neurath, A. Robert and Kent, Stephen B. H. and Strick, Nathan (1984) Location and Chemical Synthesis of a Pre-S Gene Coded Immunodominant Epitope of Hepatitis B Virus. Science, 224 (4647). pp. 392-395. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20150107-134728246

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Abstract

Immunodominant, disulfide-bond independent epitopes recognized by human antibodies to hepatitis B virus (HBV) are located within the 55-residue amino terminal portion (coded for by the pre-S region of HBV DNA) of minor HBV envelope components larger than the major protein constituents encoded by the S gene. A peptide having the sequence of the first 26 amino acids from the amino terminal methionine was synthesized and elicited antibodies (at dilutions of greater than or equal to 1 to 10^5) to the HBV envelope. These antibodies can be utilized for diagnostic tests. The immunogenicity of the peptide was substantially increased by covalent attachment to liposomes. The disulfide bond-independent determinants on sequences coded for by the pre-S gene may be more easily mimicked by peptide analogs than "conformational" determinants on the S-gene product.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.6200931DOIArticle
http://www.sciencemag.org/content/224/4647/392PublisherArticle
http://www.jstor.org/stable/1692972JSTORArticle
Additional Information:© 1984 American Association for the Advancement of Science. Received 6 February 1984; accepted 15 March 1984. We thank T. Huima, P. Sproul, and W. Lee for assistance. Partially supported by National Heart, Lung and Blood Institute grant 09011.
Funders:
Funding AgencyGrant Number
National Heart, Lung and Blood Institute09011
Issue or Number:4647
Record Number:CaltechAUTHORS:20150107-134728246
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150107-134728246
Official Citation:Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus AR Neurath, SB Kent, and N Strick Science 27 April 1984: 224 (4647), 392-395. [DOI:10.1126/science.6200931]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53293
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Jan 2015 02:50
Last Modified:03 Oct 2019 07:48

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