CaltechAUTHORS
  A Caltech Library Service

Design and Biosynthesis of Elastin-like Artificial Extracellular Matrix Proteins Containing Periodically Spaced Fibronectin CS5 Domains

Panitch, Alyssa and Yamaoka, Tetsuji and Fournier, Maurille J. and Mason, Thomas L. and Tirrell, David A. (1999) Design and Biosynthesis of Elastin-like Artificial Extracellular Matrix Proteins Containing Periodically Spaced Fibronectin CS5 Domains. Macromolecules, 32 (5). pp. 1701-1703. ISSN 0024-9297. https://resolver.caltech.edu/CaltechAUTHORS:PANm1999

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:PANm1999

Abstract

Synthetic polymers have attained a dominant position in materials science and technology largely on the basis of their excellent physical and mechanical properties. The more subtle chemical and biological properties of natural polymers, especially of the proteins and nucleic acids, have been difficult to capture in synthetic macromolecular materials, in part because these properties arise from microstructural features that cannot be controlled in statistical polymerization processes. We describe herein the use of artificial genes to direct the synthesis of polymers of precisely controlled architecture, in which biological function specifically, the capacity to support attachment of vascular endothelial cellsis the primary object of the design. A long-term objective of this work is the development of improved materials for the regeneration, replacement or repair of vascular tissue.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ma980875mDOIArticle
http://pubs.acs.org/doi/abs/10.1021/ma980875mPublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:Copyright © 1999 American Chemical Society. Received June 2, 1998; Revised Manuscript Received January 19, 1999. Publication Date (Web): February 19, 1999. This work was supported by grants from the Polymers and Genetics Programs of the National Science Foundation.
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:PANm1999
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:PANm1999
Official Citation:Design and Biosynthesis of Elastin-like Artificial Extracellular Matrix Proteins Containing Periodically Spaced Fibronectin CS5 Domains Alyssa Panitch, Tetsuji Yamaoka, Maurille J. Fournier, Thomas L. Mason, and David A. Tirrell Macromolecules 1999 32 (5), 1701-1703
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53389
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:06 Feb 2015 05:19
Last Modified:03 Oct 2019 07:49

Repository Staff Only: item control page