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Analyzing Your Complexes: Structure of the Quinol-Fumarate Reductase Respiratory Complex

Iverson, Tina M. and Luna-Chavez, César and Schröder, Imke and Cecchini, Gary and Rees, Douglas C. (2000) Analyzing Your Complexes: Structure of the Quinol-Fumarate Reductase Respiratory Complex. Current Opinion in Structural Biology, 10 (4). pp. 448-455. ISSN 0959-440X. http://resolver.caltech.edu/CaltechAUTHORS:20150108-154546091

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Abstract

The integral membrane protein complex quinol-fumarate reductase catalyzes the terminal step of a major anaerobic respiratory pathway. The homologous enzyme succinate-quinone oxidoreductase participates in aerobic respiration both as complex II and as a member of the Krebs cycle. Last year, two structures of quinol-fumarate reductases were reported. These structures revealed the cofactor organization linking the fumarate and quinol sites, and showed a cofactor arrangement across the membrane that is suggestive of a possible energy coupling function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0959-440X(00)00113-5 DOIArticle
http://www.sciencedirect.com/science/article/pii/S0959440X00001135PublisherArticle
Contact Email Address:phoebe@caltech.edu
Additional Information:© 2000 Elsevier Science Ltd. This work has been supported by the Department of Veterans Affairs (GC) and funding from the Howard Hughes Medical Institute (DCR), National Institutes of Health grants GM45162 (DCR) and HL-16251 (GC), and National Science Foundation grant MCB-9729778 (GC). We would like to acknowledge stimulating discussions with T Ohnishi, PL Dutton, HB Gray and S Iwata.
Funders:
Funding AgencyGrant Number
Department of Veterans AffairsUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHGM45162
NIHHL-16251
NSFMCB-9729778
Subject Keywords:Quinol fumarate reductase; Succinate quinone oxidoreductase; Succinate dehydrogenase; Complex II; Respiratory complexes; Flavoenzymes; Iron-sulfur proteins; Fumarate reductase; Membrane protein structure; Energy transduction
Record Number:CaltechAUTHORS:20150108-154546091
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20150108-154546091
Official Citation:Tina M Iverson, César Luna-Chavez, Imke Schröder, Gary Cecchini, Douglas C Rees, Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex, Current Opinion in Structural Biology, Volume 10, Issue 4, 1 August 2000, Pages 448-455, ISSN 0959-440X, http://dx.doi.org/10.1016/S0959-440X(00)00113-5. (http://www.sciencedirect.com/science/article/pii/S0959440X00001135)
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ID Code:53414
Collection:CaltechAUTHORS
Deposited By: SWORD User
Deposited On:14 Jan 2015 07:28
Last Modified:14 Jan 2015 07:28

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