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Analyzing Your Complexes: Structure of the Quinol-Fumarate Reductase Respiratory Complex

Iverson, Tina M. and Luna-Chavez, César and Schröder, Imke and Cecchini, Gary and Rees, Douglas C. (2000) Analyzing Your Complexes: Structure of the Quinol-Fumarate Reductase Respiratory Complex. Current Opinion in Structural Biology, 10 (4). pp. 448-455. ISSN 0959-440X. doi:10.1016/S0959-440X(00)00113-5.

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The integral membrane protein complex quinol-fumarate reductase catalyzes the terminal step of a major anaerobic respiratory pathway. The homologous enzyme succinate-quinone oxidoreductase participates in aerobic respiration both as complex II and as a member of the Krebs cycle. Last year, two structures of quinol-fumarate reductases were reported. These structures revealed the cofactor organization linking the fumarate and quinol sites, and showed a cofactor arrangement across the membrane that is suggestive of a possible energy coupling function.

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URLURL TypeDescription DOIArticle
Rees, Douglas C.0000-0003-4073-1185
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Additional Information:© 2000 Elsevier Science Ltd. This work has been supported by the Department of Veterans Affairs (GC) and funding from the Howard Hughes Medical Institute (DCR), National Institutes of Health grants GM45162 (DCR) and HL-16251 (GC), and National Science Foundation grant MCB-9729778 (GC). We would like to acknowledge stimulating discussions with T Ohnishi, PL Dutton, HB Gray and S Iwata.
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Department of Veterans AffairsUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:Quinol fumarate reductase; Succinate quinone oxidoreductase; Succinate dehydrogenase; Complex II; Respiratory complexes; Flavoenzymes; Iron-sulfur proteins; Fumarate reductase; Membrane protein structure; Energy transduction
Issue or Number:4
Record Number:CaltechAUTHORS:20150108-154546091
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Official Citation:Tina M Iverson, César Luna-Chavez, Imke Schröder, Gary Cecchini, Douglas C Rees, Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex, Current Opinion in Structural Biology, Volume 10, Issue 4, 1 August 2000, Pages 448-455, ISSN 0959-440X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53414
Deposited By: SWORD User
Deposited On:14 Jan 2015 07:28
Last Modified:10 Nov 2021 20:01

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