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Structural Bioenergetics and Energy Transduction Mechanisms

Rees, Douglas C. and Howard, James B. (1999) Structural Bioenergetics and Energy Transduction Mechanisms. Journal of Molecular Biology, 293 (2). pp. 343-350. ISSN 0022-2836. doi:10.1006/jmbi.1999.3005.

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Life depends on transduction processes that couple cellular metabolism to environmental energy sources such as light or reduced compounds. These primary energy sources must be efficiently converted into forms that can be utilized by cells for biosynthesis, motility, transport, regulation, and other metabolic functions. In recent years, there has been an explosive increase in the determination of structures for proteins mediating energy transduction processes. These developments provide the opportunity to evaluate the structural basis for the efficient coupling of two energetic processes, which defines the area of structural bioenergetics. Here, we present some general features of energy transduction processes, including arguments that effective coupling of two processes by a transduction protein occurs by way of conformational states that are common to the catalysis of each process. This is illustrated by examples from the nucleotide switch family of proteins, with emphasis on the nitrogenase system where ATP hydrolysis is coupled to an electron transfer reaction.

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Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 1999 Academic Press. We thank group members and collaborators for discussions and their contributions to the nitrogenase work from the authors' labs. This work was supported in part by NIH grant GM45162.
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Subject Keywords:biological energy transduction; nucleotide switch proteins; G-proteins; nitrogenase
Issue or Number:2
Record Number:CaltechAUTHORS:20150108-155622819
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Official Citation:Douglas C. Rees, James B. Howard, Structural bioenergetics and energy transduction mechanisms, Journal of Molecular Biology, Volume 293, Issue 2, 22 October 1999, Pages 343-350, ISSN 0022-2836, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53421
Deposited By: SWORD User
Deposited On:13 Jan 2015 17:47
Last Modified:10 Nov 2021 20:01

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