Faham, Salem and Linhardt, Robert J. and Rees, Douglas C. (1998) Diversity Does Make a Difference: Fibroblast Growth Factor-Heparin Interactions. Current Opinion in Structural Biology, 8 (5). pp. 578-586. ISSN 0959-440X. https://resolver.caltech.edu/CaltechAUTHORS:20150108-160400458
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Abstract
Fibroblast growth factors (FGFs) are members of a protein family with a broad range of biological activities. The best characterized FGFs interact with two distinct extracellular receptors — a transmembrane tyrosine kinase FGF receptor (FGFR) and a heparan sulfate-related proteoglycan of the extracellular matrix. These components form a FGF—FGFR—proteoglycan complex that activates the FGF-mediated signal transduction process through FGFR dimerization. Recent crystal structure determinations of FGF—heparin complexes have provided insights into both the interactions between these components and the role of heparin-like proteoglycans in FGF function. Future advances in this field will benefit enormously from an ability to specifically prepare homogenous heparin-based oligosaccharides of defined sequence for use in biochemical and structural studies of FGF and many other systems.
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| Additional Information: | © 1998 Current Biology Ltd. We thank T Arakawa, JR Fromm, GM Fox, RE Hileman and D Bar-Shalom for discussions of FGF and hepatic-related research conducted in the authors' laboratories, and A DiGabriele and WA Hendrickson for providing a preprint of their work on the FGF-l-heparin structure. SF was supported by the Alexander Hollaender Distinguished Postdoctoral Fellowship Program, sponsored by the DOE-OHER. Support for RJL was from National Institutes of Health grants GM38060 and HL52622. | |||||||||
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| Issue or Number: | 5 | |||||||||
| Record Number: | CaltechAUTHORS:20150108-160400458 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20150108-160400458 | |||||||||
| Official Citation: | Salem Faham, Robert J Linhardt, Douglas C Rees, Diversity does make a difference: fibroblast growth factor-heparin interactions, Current Opinion in Structural Biology, Volume 8, Issue 5, October 1998, Pages 578-586, ISSN 0959-440X, http://dx.doi.org/10.1016/S0959-440X(98)80147-4. (http://www.sciencedirect.com/science/article/pii/S0959440X98801474) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 53426 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | SWORD User | |||||||||
| Deposited On: | 13 Jan 2015 16:17 | |||||||||
| Last Modified: | 03 Oct 2019 07:49 |
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