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Diversity Does Make a Difference: Fibroblast Growth Factor-Heparin Interactions

Faham, Salem and Linhardt, Robert J. and Rees, Douglas C. (1998) Diversity Does Make a Difference: Fibroblast Growth Factor-Heparin Interactions. Current Opinion in Structural Biology, 8 (5). pp. 578-586. ISSN 0959-440X. https://resolver.caltech.edu/CaltechAUTHORS:20150108-160400458

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Abstract

Fibroblast growth factors (FGFs) are members of a protein family with a broad range of biological activities. The best characterized FGFs interact with two distinct extracellular receptors — a transmembrane tyrosine kinase FGF receptor (FGFR) and a heparan sulfate-related proteoglycan of the extracellular matrix. These components form a FGF—FGFR—proteoglycan complex that activates the FGF-mediated signal transduction process through FGFR dimerization. Recent crystal structure determinations of FGF—heparin complexes have provided insights into both the interactions between these components and the role of heparin-like proteoglycans in FGF function. Future advances in this field will benefit enormously from an ability to specifically prepare homogenous heparin-based oligosaccharides of defined sequence for use in biochemical and structural studies of FGF and many other systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0959-440X(98)80147-4 DOIArticle
http://www.sciencedirect.com/science/article/pii/S0959440X98801474PublisherArticle
ORCID:
AuthorORCID
Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 1998 Current Biology Ltd. We thank T Arakawa, JR Fromm, GM Fox, RE Hileman and D Bar-Shalom for discussions of FGF and hepatic-related research conducted in the authors' laboratories, and A DiGabriele and WA Hendrickson for providing a preprint of their work on the FGF-l-heparin structure. SF was supported by the Alexander Hollaender Distinguished Postdoctoral Fellowship Program, sponsored by the DOE-OHER. Support for RJL was from National Institutes of Health grants GM38060 and HL52622.
Funders:
Funding AgencyGrant Number
NIHGM38060
NIHHL52622
Alexander Hollaender Distinguished Postdoctoral FellowshipUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20150108-160400458
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20150108-160400458
Official Citation:Salem Faham, Robert J Linhardt, Douglas C Rees, Diversity does make a difference: fibroblast growth factor-heparin interactions, Current Opinion in Structural Biology, Volume 8, Issue 5, October 1998, Pages 578-586, ISSN 0959-440X, http://dx.doi.org/10.1016/S0959-440X(98)80147-4. (http://www.sciencedirect.com/science/article/pii/S0959440X98801474)
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ID Code:53426
Collection:CaltechAUTHORS
Deposited By: SWORD User
Deposited On:13 Jan 2015 16:17
Last Modified:03 Oct 2019 07:49

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