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Tuning the response of a pH-sensitive membrane switch

Thomas, James L. and You, Hong and Tirrell, David A. (1995) Tuning the response of a pH-sensitive membrane switch. Journal of the American Chemical Society, 117 (10). pp. 2949-2950. ISSN 0002-7863. doi:10.1021/ja00115a039. https://resolver.caltech.edu/CaltechAUTHORS:THOjacs1995

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Abstract

We have shown that the hydrophobic polyelectrolyte poly-(2-ethylacrylic acid) (PEAA, 1) causes destabilization of lipid bilayer membranes at pH 6.55 or lower and that this pH-sensitive [compound 1] response can be used to trigger release of hydrophilic compounds entrapped in liposomes. Responsive membrane systems are finding increasingly important applications in drug delivery, signal amplification in biochemical assay, and molecular recognition.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00115a039DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00115a039PublisherArticle
ORCID:
AuthorORCID
Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1995 American Chemical Society. Received November 14, 1994. This work was supported by grants from the NSF Materials Research Laboratory at the University of Massachusetts and from the U.S. Army Research Office.
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
Army Research Office (ARO)UNSPECIFIED
Issue or Number:10
DOI:10.1021/ja00115a039
Record Number:CaltechAUTHORS:THOjacs1995
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:THOjacs1995
Official Citation:Tuning the response of a pH-sensitive membrane switch James L. Thomas, Hong You, and David A. Tirrell Journal of the American Chemical Society 1995 117 (10), 2949-2950
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53482
Collection:CaltechAUTHORS
Deposited By: Anne Hormann
Deposited On:29 Jan 2015 05:36
Last Modified:10 Nov 2021 20:02

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