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Tuning the response of a pH-sensitive membrane switch

Thomas, James L. and You, Hong and Tirrell, David A. (1995) Tuning the response of a pH-sensitive membrane switch. Journal of the American Chemical Society, 117 (10). pp. 2949-2950. ISSN 0002-7863. doi:10.1021/ja00115a039.

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We have shown that the hydrophobic polyelectrolyte poly-(2-ethylacrylic acid) (PEAA, 1) causes destabilization of lipid bilayer membranes at pH 6.55 or lower and that this pH-sensitive [compound 1] response can be used to trigger release of hydrophilic compounds entrapped in liposomes. Responsive membrane systems are finding increasingly important applications in drug delivery, signal amplification in biochemical assay, and molecular recognition.

Item Type:Article
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Tirrell, David A.0000-0003-3175-4596
Additional Information:© 1995 American Chemical Society. Received November 14, 1994. This work was supported by grants from the NSF Materials Research Laboratory at the University of Massachusetts and from the U.S. Army Research Office.
Funding AgencyGrant Number
Army Research Office (ARO)UNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:THOjacs1995
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Official Citation:Tuning the response of a pH-sensitive membrane switch James L. Thomas, Hong You, and David A. Tirrell Journal of the American Chemical Society 1995 117 (10), 2949-2950
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:53482
Deposited By: Anne Hormann
Deposited On:29 Jan 2015 05:36
Last Modified:10 Nov 2021 20:02

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